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Thromb Haemost 1973; 30(03): 531-540
DOI: 10.1055/s-0038-1649131
Original Article
Schattauer GmbH

Effect of Corticosteroids upon Fibrinogen Metabolism in Rabbits

Uri Seligsohn
1   Department of Medicine, University of Southern California School of Medicine, Los Angeles, California 90033
,
Samuel I. Rapaport
1   Department of Medicine, University of Southern California School of Medicine, Los Angeles, California 90033
,
Stephen M.-C. Shen
1   Department of Medicine, University of Southern California School of Medicine, Los Angeles, California 90033
,
Paul R. Kuefler
1   Department of Medicine, University of Southern California School of Medicine, Los Angeles, California 90033
› Author Affiliations
Further Information

Publication History

Received 01 August 1973

Accepted 06 October 1973

Publication Date:
30 June 2018 (online)

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Summary

The effect of pharmacologic doses of adrenal corticosteroids upon plasma fibrinogen level, incorporation of 75Se-Methionine (75SeM) into fibrinogen, and disappearance of plasma 125I-fibrinogen was evaluated in rabbits. Single 25 mg doses of hydrocortisone or cortisone transiently increased both 75SeM incorporation into fibrinogen and plasma fibrinogen levels, but 1 to 5 mg doses of hydrocortisone had no significant effect upon plasma fibrinogen levels. Repeated daily injections of 25 mg of hydrocortisone did not increase plasma fibrinogen levels progressively. Two doses of 25 mg of hydrocortisone, given 24 hr apart, failed to alter the rate of disappearance of plasma 125I-fibrinogen radioactivity, i.e., plasma fibrinogen catabolism. Intramuscular injection of 2.5 ml of propylene glycol solvent caused a prolonged rise in plasma fibrinogen level, whereas injection of 25 mg of corticosterone dissolved in propylene glycol resulted in an attenuated and transient rise in plasma fibrinogen level. Apparently, the presence or absence of a coexistent inflammatory stimulus determines the overall effect of large pharmacologic doses of corticosteroids upon fibrinogen metabolism in the rabbit. In the presence of inflammation, corticosteroids decrease synthesis with a resultant fall in plasma fibrinogen level; in the absence of inflammation, corticosteroids may increase synthesis transiently with a resultant slight increase in plasma fibrinogen level.

 

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