Summary
Immunochemical, physical, and anticoagulant properties of human and monkey (Macaca irus) fibrinogen degradation products (FDP’s) were compared by Immunoelectrophoresis, Sephadex G-200 gel filtration, and anticoagulant assay. Both species demonstrated a high degree of similarity in the properties and sequence of generation of FDP’s derived from in vitro plasmin digestion of highly purified fibrinogen. The results of this study should permit a closer analogy to be drawn between the pathogenic mechanisms of disseminated intravascular coagulation occurring experimentally in monkeys and clinically in humans.
