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Thromb Haemost 1974; 31(02): 328-338
DOI: 10.1055/s-0038-1649167
Original Article
Schattauer GmbH

Studies on the Characterization of Factor VIII and a Co-factor VIII

M. M. P Paulssen
1   Department of Clinical biochemistry, St. Clara Hospital, Rotterdam, Netherlands
2   Central Animal Laboratory of the University of Nijmegen, Netherlands (Head: Dr. M. J. Dobbelaar)
,
H. L. M. A Vandenbussche-Scheffers
1   Department of Clinical biochemistry, St. Clara Hospital, Rotterdam, Netherlands
2   Central Animal Laboratory of the University of Nijmegen, Netherlands (Head: Dr. M. J. Dobbelaar)
,
P. B Spaan
1   Department of Clinical biochemistry, St. Clara Hospital, Rotterdam, Netherlands
2   Central Animal Laboratory of the University of Nijmegen, Netherlands (Head: Dr. M. J. Dobbelaar)
,
T de Jong
1   Department of Clinical biochemistry, St. Clara Hospital, Rotterdam, Netherlands
2   Central Animal Laboratory of the University of Nijmegen, Netherlands (Head: Dr. M. J. Dobbelaar)
,
M. C Planje
1   Department of Clinical biochemistry, St. Clara Hospital, Rotterdam, Netherlands
2   Central Animal Laboratory of the University of Nijmegen, Netherlands (Head: Dr. M. J. Dobbelaar)
› Author Affiliations
Further Information

Publication History

Received 29 May 1973

Accepted 16 January 1974

Publication Date:
29 June 2018 (online)

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Summary

Factor VIII occurs in the body in two different forms. In lymph factor VIII is bound to chylomicra. In plasma, factor VIII is bound to a protein.

After delipidation of chylomicra we obtained a glycoprotein with a high polysaccharide content and a molecular weight of approx. 160,000.

In plasma, factor VIII is attached to a protein which is present in normal concentrations in plasma of patients with haemophilia A and in serum (co-factor VIII).

This factor is deficient in both the plasma and the serum of patients with von Willebrand’s disease.

The binding between factor VIII and co-factor VIII is reversible.

Some properties of these two factors are described.

 

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