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Thromb Haemost 1974; 31(03): 505-512
DOI: 10.1055/s-0038-1649190
Original Article
Schattauer GmbH

Prolonged Plasma Clotting Time and Decreased Fibrinolysis after Long Term Treatment with α-Tocopherol

K Korsan-Bengtsen
1   Blood Coagulation Laboratory, Department of Medicine II, Sahlgren’s hospital, 413 45 Göteborg, Sweden
,
D Elmfeldt
1   Blood Coagulation Laboratory, Department of Medicine II, Sahlgren’s hospital, 413 45 Göteborg, Sweden
,
T Holm
1   Blood Coagulation Laboratory, Department of Medicine II, Sahlgren’s hospital, 413 45 Göteborg, Sweden
› Author Affiliations
Further Information

Publication History

Received 30 December 1973

Accepted 10 March 1974

Publication Date:
29 June 2018 (online)

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Summary

Blood platelet function, blood clotting and fibrinolysis were studied in a group of 9 male post myocardial infarction patients once a week for 5 consecutive weeks after which α-tocopherol 300 mg/day was given. The group was again investigated after 2, 6, 18, 44 and 64 weeks of α-tocopherol treatment. After 18, 44 and 64 weeks of treatment a highly significant prolongation of the plasma clotting time was observed. On the basis of the analyses made it is concluded that the prolongation is probably due to a decreased platelet factor 3 activity. The ability to increase fibrinolytic activity after stasis of the arm is reduced after long term α-tocopherol treatment. There were no changes in the number of platelets, platelet adhesiveness, factor II-VII-X activity, factor VIII, fibrinogen, antithrombin III, α1-antitrypsin, α2-macroglobulin, total anti-fibrinolytic activity or plasminogen. Our hypothesis to explain the results is that α-tocopherol influences on the cell membranes of the platelets and the endothelial cells and thus causes a reduced release of platelet factor 3 and activators of fibrinolysis. This is in line with many other observations indicating that α-tocopherol is of importance for the cell membrane function.

 

  • References

  • 1 Berg W, Korsan-Bengtsen K, Ygge J. Determination of plasminogen in human plasma by the lysis time method. Thrombosis et Diathesis Haemorrhagica 1966; 16: 1
    PubMedSearch in Google Scholar
  • 2 Blaxter K. L. Vitamin E in health and disease of cattle and sheep. Vitamins & Hormones 1962; 20: 63
    PubMedSearch in Google Scholar
  • 3 Blombäck B. On the properties of fibrinogen and fibrin. Arkiv Kemi 1958; 12: 99
    PubMedSearch in Google Scholar
  • 4 Boyd A. M, Marks J. Treatment of intermittent claudication. A reappraisal of the value of α-tocopherol. Angiology 1963; 14: 198
    CrossrefPubMedSearch in Google Scholar
  • 5 Gautheron P, Renaud S. Hyperlipemia induced hypercoagulable state in rat. Role of an increased activity of platelet phosphatidyl serine in response to certain dietary fatty acids. Thrombosis Research 1972; 1: 353
    CrossrefPubMedSearch in Google Scholar
  • 6 Gross S, Melhorn D. K. Vitamin E, red cell lipids and red cell stability in prematurity. Annals of The New York Academy of Sciences 1972; 203: 141
    CrossrefPubMedSearch in Google Scholar
  • 7 Hardisty R. M, McPherson J. G. A one stage factor VIII (antihemophilic globulin) assay and its use on venous and capillary plasma. Thrombosis et Diathesis Haemorrhagica 1962; 7: 215
    PubMedSearch in Google Scholar
  • 8 Hellem A. J. The adhesiveness of human blood platelets in vitro. Scandinavian Journal of Clinical and Laboratory Investigation 1960; 12 suppl. 51
    PubMedSearch in Google Scholar
  • 9 Haeger K. The treatment of peripheral occlusive arterial disease with α-tocopherol as compared with vasodilator agents and antiprothrombin (dicumarol). Vascular Disease 1968; 5: 199
    PubMedSearch in Google Scholar
  • 10 Korsan-Bengtsen K. Comparison between various methods used to control dicumarol therapy. Acta Medica Scandinavica 1970; 188: 327
    PubMedSearch in Google Scholar
  • 11 Korsan-Bengtsen K, Wilhelmsen L, Elmfeldt D, Tibblin G. Blood coagulation and fibrinolysis in man after myocardial infarction compared with a representative population sample. Atherosclerosis 1972; 16: 83
    CrossrefPubMedSearch in Google Scholar
  • 12 Korsan-Bengtsen K, Stenberg J, Sjöström L, Bjorntorp P, Sullivan L. Blood coagulation fibrinolysis and platelet function in obese subjects at rest and after maximal exercise. Thrombosis Research 1972; 1: 389
    CrossrefPubMedSearch in Google Scholar
  • 13 Korsan-Bengtsen K, Wilhelmsen L, Tibblin G. Blood coagulation and fibrinolysis in a random sample of 788 men 54 years old. I. Correlations between the variables of clotting and fibrinolysis. Thrombosis et Diathesis Haemorrhagica 1972; 28: 89
    PubMedSearch in Google Scholar
  • 14 Leonard P, Losowsky M. S. Effect of alpha-tocopherol administration on red cell survival in vitamin E-deficient human subjects. The American Journal of Clinical Nutrition 1971; 24: 388
    CrossrefPubMedSearch in Google Scholar
  • 15 Lucy J. A. Functional and structural aspects of biological membranes: A suggested structural role for vitamin E in the control of membrane permeability and stability. Annals of The New York Academy of Sciences 1972; 203: 4
    CrossrefPubMedSearch in Google Scholar
  • 16 Mancini G, Carbonara A. O, Hereman J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. International Journal of Immuno-chemistry 1972; 2: 235
    PubMedSearch in Google Scholar
  • 17 Nair P. P. Vitamine E and metabolic regulation. Annals of The New York Academy of Sciences 1972; 203: 53
    CrossrefPubMedSearch in Google Scholar
  • 18 Nordöy A, Rödset M. Platelet phospholipids and their function in patients with ischemic heart disease. Acta Medica Scandinavica 1970; 188: 133
    PubMedSearch in Google Scholar
  • 19 Osk I. F. A, Barness L. A. Hemolytic anemia in vitamin E deficiency. American Journal of Clinical Nutrition 1968; 21: 45
    CrossrefPubMedSearch in Google Scholar
  • 20 Williams H. T. G, Fenna D, Macbeth R. A. Alpha tocopherol in the treatment of intermittent claudication. Surgery Gynecology and Obstetrics 1971; 132: 662
    PubMedSearch in Google Scholar
  • 21 Withing L. A, Horwitt M. K. Effect of degree of fatty acid unsaturation in tocopherol deficiency-induced creatinuria. Nutrition 1964; 82: 19
    PubMedSearch in Google Scholar
  • 22 Ygge J, Berg W, Korsan-Bengtsen K. Assay of the antifibrinolytic activity in human plasma by means of the lysis time method. Thrombosis et Diathesis Haemorrhagica 1968; 20: 561
    PubMedSearch in Google Scholar