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Thromb Haemost 1977; 37(01): 029-035
DOI: 10.1055/s-0038-1649198
Original Article
Schattauer GmbH

The Effect of Phospholipase C on Platelet Factor 3 in Human Blood Platelets

A-B Otnaess
1   Institute of Medical Biology, University of TromsØ, TromsØ, Norway
,
H Prydz *
1   Institute of Medical Biology, University of TromsØ, TromsØ, Norway
› Author Affiliations
Further Information

Publication History

Received 11 January 1976

Accepted 23 September 1976

Publication Date:
24 July 2018 (online)

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Summary

Intact human platelets isolated by gel filtration have been treated with purified phospholipase C. The effect of the enzyme on available and total platelet factor 3 has been tested.

The available procoagulant platelet factor 3 was very low. A further small reduction was observed after incubation with phospholipase C when the enzyme was washed away before testing.

External attack on platelets by phospholipase C led to a marked inactivation of total platelet factor 3.

 

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