Kinetic Aspects of the Interaction of Blood Clotting Enzymes

Thromb Haemost 1977; 37(01): 081-085
DOI: 10.1055/s-0038-1649204

Original Article

Schattauer GmbH

VII. The Relation between Clotting Time and Prothrombin Concentration

H. C Hemker

¹Department of Biochemistry, Biomedical Centre, State University Limburg, Maastricht, The Netherlands

,

C Vermeer

¹Department of Biochemistry, Biomedical Centre, State University Limburg, Maastricht, The Netherlands

,

J Govers-Riemslag

¹Department of Biochemistry, Biomedical Centre, State University Limburg, Maastricht, The Netherlands

The relation between clotting time and the inverse of prothrombin concentration is shown to be rectilinear.

References
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2 Hemker H.C, Muller A.D. Kinetic aspects of the interaction of blood clotting enzymes. V. One-stage estimations in the extrinsic coagulation system. Thrombosis et Diathesis Haemorrhagica 1968; 19: 368
3 Hemker H.C, Swart A.C.W, Alink A.M.J. Artifícal reagents for factor VII and X, a computer program for obtaining reference tables for one-stage determinations in the extrinsic system. Thrombosis et Diathesis Haemorrhagica 1972; 27: 205
4 Owen W.G, Esmon G.T, Jackson W.M. The conversion of prothrombin to thrombin. I. Characterization of the reaction products formed during the activation of bovine prothrombin. Journal of Biological Chemistry 1974; 249: 594
5 Vermeer C, Soute B.A.M, Hemker H.C. A new method for the preparation of artificial factor II reagents from normal human and bovine plasma. Submitted for publication 1976