A New Method for the Determination of Plasma Activators of Fibrinolysis

R Margalit; E Gidron; Y Shalitin

doi:10.1055/s-0038-1649221

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1977; 37(02): 210-215
DOI: 10.1055/s-0038-1649221

Original Article

Schattauer GmbH

A New Method for the Determination of Plasma Activators of Fibrinolysis

R Margalit

¹Clinical Research Laboratory, Department of Medicine B, Rothschild University Hospital and the Department of Biology, Technion – Israel Institute of Technology, Haifa, Israel.

,

E Gidron

¹Clinical Research Laboratory, Department of Medicine B, Rothschild University Hospital and the Department of Biology, Technion – Israel Institute of Technology, Haifa, Israel.

,

Y Shalitin

¹Clinical Research Laboratory, Department of Medicine B, Rothschild University Hospital and the Department of Biology, Technion – Israel Institute of Technology, Haifa, Israel.

› Institutsangaben

Abstract

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Summary

The term “effective activator” of plasminogen is proposed, to denote the resultant of activator-antiactivator interaction, and a method for the determination of the level of these activators is described. By adding axcess plasminogen to the euglobulin fraction of plasma the influence of the level of endogenous plasminogen and of the antiplasmin is eliminated. It is shown that the level of fibrinogen has very little bearing on the results. An effective activator unit is defined as equal to 1 CTA unit of urokinase activity on a fibrinogen-plasminogen substrate.

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Referenzen

References
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3 Schwert G.W, Takenaka Y. A spectrophotometric determination of trypsin and chymo-trypsin. Biochemica Biophysica Acta 1955; 16: 570
4 Schwick H.G, Heimburger R.N, Haupt H. Antiproteinasen des Humanserums. Zeitschrift für die Gesamte Innere Medizin 1966; 21: 193