The Plasminogen Activator of the Arterial Wall

L Donner; P Klener; Z Roth

doi:10.1055/s-0038-1649252

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1977; 37(03): 436-443
DOI: 10.1055/s-0038-1649252

Original Article

Schattauer GmbH

The Plasminogen Activator of the Arterial Wall

L Donner

¹Department of Medicine, Charles University, Division of Haematology and the Department of Mathematical Statistics and Programming, Institute of Hygiene and Epidemiology, Prague, Czechoslovakia

,

P Klener

¹Department of Medicine, Charles University, Division of Haematology and the Department of Mathematical Statistics and Programming, Institute of Hygiene and Epidemiology, Prague, Czechoslovakia

,

Z Roth

¹Department of Medicine, Charles University, Division of Haematology and the Department of Mathematical Statistics and Programming, Institute of Hygiene and Epidemiology, Prague, Czechoslovakia

› Author Affiliations

Abstract

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Summary

The plasminogen activator in 645 specimens of various human arteries – thoracic, abdominal aorta, carotic, pulmonary, renal, basilar, coronary – was studied using Todd’s histochemi-cal method. 92 cadavers were used, 1–18 hours post mortem from subjects aged from 272 days to 83 years. 45 specimens of pulmonary, renal and splenic arteries were obtained during surgery.

The greatest fibrinolytic activity was within the adventitia. Intima occasionally showed very little fibrinolytic activity, or none at all.

No statistically significant differences in plasminogen activator activity were found between the various arteries examined.

A statistically significant increase in fibrinolysis in adventitia of atherosclerotic arteries was established. No correlation was found between the fibrinolytic activity of the arteries and their alkaline phosphatase content.

Some properties of the plasminogen activator of the arterial vessel wall were evaluated. Influence of storage, inactivation with epsilonaminocaproic acid and extracted with potassium thiocyanate was studied.

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References

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