Marathon Run I: Effects on Blood Coagulation and Fibrinolysis

T Mandalaki; A Dessypris; C Louizou; I Bossinakou; C Panayotopoulou; A Antonopoulou

doi:10.1055/s-0038-1649253

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1977; 37(03): 444-450
DOI: 10.1055/s-0038-1649253

Original Article

Schattauer GmbH

Marathon Run I: Effects on Blood Coagulation and Fibrinolysis

T Mandalaki

¹2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi) Greece, and The Minerva Foundation Institute for Medical Research, Endocrine Research Laboratory, University of Helsinki, Finland

,

A Dessypris

¹2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi) Greece, and The Minerva Foundation Institute for Medical Research, Endocrine Research Laboratory, University of Helsinki, Finland

,

C Louizou

¹2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi) Greece, and The Minerva Foundation Institute for Medical Research, Endocrine Research Laboratory, University of Helsinki, Finland

,

I Bossinakou

¹2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi) Greece, and The Minerva Foundation Institute for Medical Research, Endocrine Research Laboratory, University of Helsinki, Finland

,

C Panayotopoulou

¹2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi) Greece, and The Minerva Foundation Institute for Medical Research, Endocrine Research Laboratory, University of Helsinki, Finland

,

A Antonopoulou

¹2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi) Greece, and The Minerva Foundation Institute for Medical Research, Endocrine Research Laboratory, University of Helsinki, Finland

› Institutsangaben

Abstract

als PDF herunterladen

Summary

Blood coagulation and fibrinolysis were assessed in 13 Finnish amateur runners aged 31 to 48, and one 65-year old taking part in a non-competitive marathon (42.2 km). After the run the mean values of partial thromboplastin time showed a very significant shortening, whereas the mean values of the prothrombin time and of plasma fibrinogen were not significantly altered. The mean values of euglobulin lysis time were significantly shorter and the mean values of fibrin degradation products increased highly significantly. After the run, protamine sulphate was positive or strongly positive in all subjects, whereas the ethanol gelation test was negative in all runners; no cryofibrinogen was detected in any participant. Thus, running a marathon race affects the haemostatic balance and activates the fibrinolytic mechanism. The effects of training and physical fitness on the above parameters are discussed.

PDF (6157 kb)

Referenzen

References
1 Biggs R, MacFarlane R. G, Pilling J. Observations on fibrinolysis. Experimental activity produced by exercise or adrenaline. Lancet I 1947; 402
2 Billimoria J. D, Drysdale J, James D. C. O, Maclagan N. F. Determination of fibrinolytic activity of whole blood with special reference to the effects of exercise and fat feeding. Lancet 1959; II: 471
3 Cash J. D. Effect of moderate exercise on the fibrinolytic system in normal young men and women. British Medical Journal 1966; II: 502
4 Clauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematologica 1957; 15: 237
5 Cepelak V, Cepelakova H. Circadian periodicity of fibrinolysis and clinical trials. Third International Conference on Synthetic Fibrinolytic-Thrombolytic Agents, Glasgow, Abstract No. 54 1976
6 De-Jonge H. Inleiding tot de Medische Statistiek. Deel II. Verhandeling van het Nederlands Institut voor Praeventive Geneeskunde, Leiden 2nd Edit. 1964: 486
7 Egeberg O. Changes in the activity of antihemophilic A factor (F. VIII) and in the bleeding time associated with muscular exercise and adrenalin infusion. Scandinavian Journal of Clinical and Laboratory Investigation 1963; 15: 539
8 Fearnley G. R, Lackner R. The fibrinolytic acitivity of normal blood. British Journal of Haematology 1955; 1: 189
9 Ferguson E. W, Guest M. M. Exercise, physical conditioning blood coagulation and fibrinolysis. Thrombosis et diathesis haemorrhagica (Stuttg.) 1974; 31: 63
10 Godal H. C, Abildgaard U. Gelation of soluble fibrin in plasma by ethanol. Scandinavian Journal of Haematology 1966; 3: 342
11 Iatridis S. G, Ferguson J. H. Effect of physical exercise on blood clotting and fibrinolysis. Journal of Applied Physiology 1963; 18: 337
12 Ikkala E, Myllylä G, Sarajas H. S. S. Haemostatic changes associated with exercise. Nature 1963; 199: 459
13 Karvonen M. J, Klemola H, Virkajärvi J, Kekkonen A. Longenivity of endurance skiers. Medicine and Science in Sports 1974; 6: 49
14 Lipinsky B, Gurewich V, Lipinska I. A comparative study of protamine sulphate precipitation paracoagulation and ethanol gelation. IV th International Congress on Thrombosis and Haemostasis, Vienna, Abstract 203 1973
15 Mandalaki T, Dessypris A, Antonopoulou A, Bossinakou I. Fibrin degradation products after intense exercise. Archives of Medical Societies. Athens 1973; 1: 17
16 Mann R. D. Effect of age, sex, and diurnal variation on the human fibrinolytic system. Journal of Clinical Pathology 20 1967; 223
17 Merskey G, Lalezari R, Johnson A. J. A rapid simple sensitive method for measuring fibrinolytic split products in human serum. Proceedings of the Society for Experimental Biology and Medicine 1969; 131: 781
18 Menon I. S, Burke F, Dewar H. A. Effect of strenuous and graded exercise on fibrinolytic activity. Lancet 1967; I: 700
19 Niewiarowski S, Gurewich V. Laboratory identification of intravascular coagulation. The serial dilution protamine sulphate test for the detection of fibrin monomer and fibrin degradation products. Journal of Laboratory and Clinical Medicine 1971; 77: 665
20 Ogston D, Fullerton H. W. Changes in fibrinolytic activity produced by physical activity. Lancet 1961; II: 730
21 Ogston D, McDonald G. A, Fullerton H. W. The influences of anxiety in tests of blood coagulability and fibrinolytic acitivty. Lancet 1962; 521 II
22 Palmblad J, Blombäck M, Egberg N, Fröberg J, Karlsson C. G, Levi L. Experimentally induced stress in man. Effects on blood coagulation and fibrinolysis. Report No. 42 from the Laboratory for Clin. Stress Research, Karolinska; Sjukhuset Stockholm 60 1975
23 Panayotopoulou C. Fibrin monomers and fibrinogen/fibrin breakdown products to healthy subjects. Doctoral Thesis, Athens. 1974
24 Rosing D. R, Brakman P, Redwood D. R, Goldstein R. E, Beiser G. D, Astrup T, Epstein S. E. Blood fibrinolytic activity in man. Diurnal variation and the response to varying intensities of exercise. Circulation Research 1970; 27: 171
25 Shainof I. R, Page I. H. Significance of cryoprofibrin in fibrinogen fibrin conversion. Journal of Experimental Medicine 1962; 116: 687
26 Sherry S, Lindermayer R, Fletcher R. P, Alkjaersig N. Studies on enhanced fibrinolytic activity in man. Journal of Clinical Investigation 1959; 38: 810
27 Slaastad R. A, Godal H.C, Jeremic M. The diagnosis of lowgraded intravascular coagulation: A study in rabbits. III Congress, International Society of Thrombosis and Haemostasis, Washington, D. C. Abstract 340 1972
28 Winther O. Exercise and blood-fibrinolysis. Lancet 1966; II: 1195