Use of 125I-Fibrinogen Kinetic Data to Detect Disseminated Intravascular Coagulation and Deposition of Fibrin in Patients with Metastatic Cancer

Elean B Robson; Gail F Murawski; Richard E Bettigole

doi:10.1055/s-0038-1649259

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1977; 37(03): 484-508
DOI: 10.1055/s-0038-1649259

Original Article

Schattauer GmbH

Use of ¹²⁵I-Fibrinogen Kinetic Data to Detect Disseminated Intravascular Coagulation and Deposition of Fibrin in Patients with Metastatic Cancer

Elean B Robson

¹State University of New York at Buffalo, N. Y. 14215, U. S. A.

,

Gail F Murawski

¹State University of New York at Buffalo, N. Y. 14215, U. S. A.

,

Richard E Bettigole

¹State University of New York at Buffalo, N. Y. 14215, U. S. A.

› Author Affiliations

Abstract

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Summary

A technique using computerized data handling for following the fate of ¹²⁵I-fibrinogen through various physiological compartments is presented. Its use in detecting fibrin build up in patients with metastatic tumors and cancer-caused DIC is explained. An increase in j_3u (fractional catabolic rate as seen in the urine data) throughout the course of a study was found to be an important indicator of extravascular fibrin build up.

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References

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