Factor VIII Inhibitor Associated with Chlorpromazine-Induced Hepatic Injury

Richard L Glazier; Edward B Crowell Jr.

doi:10.1055/s-0038-1649261

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1977; 37(03): 523-526
DOI: 10.1055/s-0038-1649261

Original Article

Schattauer GmbH

Factor VIII Inhibitor Associated with Chlorpromazine-Induced Hepatic Injury

Richard L Glazier

¹Department of Medicine, University of Wisconsin, Center for Health Sciences, Madison, Wisconsin,, 53706 U.S.A.

,

Edward B Crowell Jr.

¹Department of Medicine, University of Wisconsin, Center for Health Sciences, Madison, Wisconsin,, 53706 U.S.A.

› Institutsangaben

Abstract

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Summary

A 90-year-old man was given chlorpromazine for sedation and 2 weeks later developed cholestatic jaundice and subsequently a factor VIII inhibitor. His death 4 weeks after institution of chlorpromazine, from massive bleeding, coupled with the autopsy finding of intrahepatic cholestatic jaundice, suggests that both adverse reactions were due to the drug.

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Referenzen

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