Platelet Aggregation in Diabetes Mellitus and the Effect of Insulin in Vivo on Aggregation

A. A Hassanein; Th. A El-Garf; Z El-Baz

doi:10.1055/s-0038-1649346

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1972; 27(01): 114-120
DOI: 10.1055/s-0038-1649346

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Platelet Aggregation in Diabetes Mellitus and the Effect of Insulin in Vivo on Aggregation

Authors

A. A Hassanein

¹Department of Haematology, Maadi Armed Forces Hospital, Maadi, Cairo, Egypt
Th. A El-Garf

¹Department of Haematology, Maadi Armed Forces Hospital, Maadi, Cairo, Egypt
Z El-Baz

¹Department of Haematology, Maadi Armed Forces Hospital, Maadi, Cairo, Egypt

Abstract

Summary

ADP-induced platelet aggregation and calcium-induced platelet aggregation tests were studied in 14 diabetic patients in the fasting state and half an hour after an intravenous injection of 0.1 unit insulin/kg body weight. Platelet disaggregation was significantly diminished as compared to a normal control group, and their results were negatively correlated with the corresponding serum cholesterol levels. Insulin caused significant diminution in the ADP-induced platelet aggregation as a result of rapid onset of aggregation and disaggregation. There was also a significant increase in platelet disaggregation. In the calcium-induced platelet aggregation test, there was a significant shortening of the aggregation time, its duration, and the clotting time. The optical density fall due to platelet aggregation showed a significant increase. Insulin may have a role in correcting platelet disaggregation possibly through improvement in the intracellular enzymatic activity.

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References

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