The Role of β-Fibrinogen Genotype in Determining Plasma Fibrinogen Levels in Young Survivors of Myocardial Infarction and Healthy Controls from Sweden

Fiona Green; Anders Hamsten; Margareta Blombäck; Steve Humphries

doi:10.1055/s-0038-1649699

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1993; 70(06): 0915-0920
DOI: 10.1055/s-0038-1649699

Original Article

Clinical Studies

Schattauer GmbH Stuttgart

The Role of β-Fibrinogen Genotype in Determining Plasma Fibrinogen Levels in Young Survivors of Myocardial Infarction and Healthy Controls from Sweden

Fiona Green

¹The Centre for the Genetics of Cardiovascular Disorders, Department of Medicine, University College London Medical School, The Rayne Institute, London, UK

,

Anders Hamsten

²The King Gustaf V Research Institute, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

,

Margareta Blombäck

³The Department of Clinical Chemistry and Blood Coagulation, Karolinska Hospital, Stockholm, Sweden

,

Steve Humphries

¹The Centre for the Genetics of Cardiovascular Disorders, Department of Medicine, University College London Medical School, The Rayne Institute, London, UK

› Author Affiliations

Abstract

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Summary

β-fibrinogen G/A^-455 polymorphism genotype was determined in 123 young survivors of myocardial infarction and 86 healthy controls from Sweden. Frequency of the A^-455 allele was 0.25 (95% Confidence Interval 0.21–0.29) in both patients and controls, significantly higher than that reported previously (0.19, 95% Cl 0.16–0.22) in 292 men from the UK (1). Mean plasma fibrinogen level was significantly higher in patients (3.6 g/1) than in controls (3.1 g/1), with p <0.001. Genotype was significantly associated with (adjusted) plasma fibrinogen level in controls (p = 0.003). This effect was confined to the smokers (n = 50) where mean fibrinogen level was significantly (p = 0.001) higher in G/A^-455 and A/A^-455 individuals (3.5 g/1) compared with G/G^-455 homozygotes (2.9 g/1). There was a significant interaction between smoking status and genotype in determining plasma fibrinogen levels in the controls. These data provide independent confirmation of the association between β-fibrinogen G/A^-455 genotype and plasma fibrinogen levels previously observed in healthy men from the UK (1).

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References

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