ΔC in Exon 18 of the von Willebrand Gene Is Uncommon in German vWD Type III Patients

Thromb Haemost 1993; 70(06): 1064-1065
DOI: 10.1055/s-0038-1649727

Letter to the Editor

Schattauer GmbH Stuttgart

Günter Mertes

Dept. of Exp. Haemat. and Transf. Med., University of Bonn, Bonn, Germany

,

Michael Ludwig

¹Dept. of Exp. Haemat. and Transf. Med., University of Bonn, Bonn, Germany

,

Rainer Schwaab

Dept. of Exp. Haemat. and Transf. Med., University of Bonn, Bonn, Germany

,

Hans-Her-mann Brackmann

Dept. of Exp. Haemat. and Transf. Med., University of Bonn, Bonn, Germany

,

Klaus Olek

¹Dept. of Exp. Haemat. and Transf. Med., University of Bonn, Bonn, Germany

References
1 Ruggeri ZM, Zimmermann TS. von Willebrand factor and von Willebrand disease. Blood 1987; 70: 895-904
2 Mancuso DJ, Tuley EA, Westfield LA, Worrall NK, Shelton-Inloes BB, Sorace JM, Alevy YG, Sadler JE. Structure of the gene for human von Willebrand factor. J Biol Chem 1989; 264: 19514-19527
3 Ginsburg D, Sadler JE. Von Willebrand disease: A database of point mutations insertions, and deletions. Thromb Haemostas 1993; 69: 177-184
4 Zhang ZP, Falk G, Blombäck M, Egberg N, Anvret M. A single cytosine deletion in exon 18 of the von Willebrand factor gene is the most common mutation in Swedish vWD type III patients. Hum Mol Gen 1992; 1: 767-788
5 Faber JP, Poller W, Olek K, Baumann U, Carlson J, Lindmark B, Eriksson S. The molecular basis of α₁-antichymotrypsin deficiency in a heterozygote with liver and lung disease. J Hepatol. 1993 (in press)
6 Mertes G, Ludwig M, Schwaab R, Brackmann H-H, Olek K. T/C polymorphism in the von Willebrand factor (vWF) gene at codon 795. Hum Mol Gen. 1993. (submitted)