Environmental and Genetic Factors in Relation to Elevated Circulating Levels of Plasminogen Activator Inhibitor-1 in Caucasian Patients with Non-Insulin-Dependent Diabetes Mellitus

Michael W Mansfield; Max H Stickland; Peter J Grant

doi:10.1055/s-0038-1649834

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 74(03): 842-847
DOI: 10.1055/s-0038-1649834

Original Article

Clinical Studies

Schattauer GmbH Stuttgart

Environmental and Genetic Factors in Relation to Elevated Circulating Levels of Plasminogen Activator Inhibitor-1 in Caucasian Patients with Non-Insulin-Dependent Diabetes Mellitus

Michael W Mansfield

The Diabetes and Thrombosis Research Group, Division of Medicine, School of Medicine, University of Leeds, UK

,

Max H Stickland

The Diabetes and Thrombosis Research Group, Division of Medicine, School of Medicine, University of Leeds, UK

,

Peter J Grant

The Diabetes and Thrombosis Research Group, Division of Medicine, School of Medicine, University of Leeds, UK

› Author Affiliations

Abstract

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Summary

To investigate the interaction of metabolic and genetic factors in relation to PAI-1, genotype was determined at a 4G/5G polymorphism in the PAI-1 gene promoter and at a Hind III RFLP of the PAI-1 gene in 189 Caucasian NIDDM patients. PAI-1 levels were equivalent in each genotype group and PAI-1 activity correlated with fasting insulin (r = 0.45), triglyceride (r = 0.39) body mass index (r = 0.44), cholesterol (r = 0.17) and glucose (r = 0.15). The regression slope (B) of PAI-1 activity on triglycerides was steeper in the 4G/4G group than the other two groups: 4G/4G B = 0.91, r = 0.62; 4G/5G B = 0.36, r = 0.27; 5G/5G B = 0.31, r = 0.29 (difference between slopes p = 0.02) and the association between PAI-1 activity and glucose remained only in the 4G/4G group (r = 0.35). These results confirm the association of PAI-1 levels with the features of insulin resistance and indicate that the association between PAI-1 levels and both triglyceride and glucose is influenced by genotype in the region of the PAI-1 gene promoter.

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References

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