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Thromb Haemost 1995; 74(04): 1032-1034
DOI: 10.1055/s-0038-1649875
Original Article
Clinical Studies
Schattauer GmbH Stuttgart

Plasminogen Activator Inhibitor-1 (PAI-1) Promoter Polymorphism and Coronary Artery Disease in Non-Insulin-Dependent Diabetes

Michael W Mansfield
The Diabetes and Thrombosis Research Group, Division of Medicine, Leeds General Infirmary, Leeds, UK
,
Max H Stickland
The Diabetes and Thrombosis Research Group, Division of Medicine, Leeds General Infirmary, Leeds, UK
,
Peter J Grant
The Diabetes and Thrombosis Research Group, Division of Medicine, Leeds General Infirmary, Leeds, UK
› Author Affiliations
Further Information

Publication History

Received 30 March 1995

Accepted after resubmission 05 July 1995

Publication Date:
09 July 2018 (online)

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Summary

Elevated levels of PAI-1 are found in coronary artery disease (CAD) and non-insulin-dependent diabetes (NIDDM). PAI-1 may be involved in the pathogenesis of CAD through suppression of fibrinolysis, alternatively the high levels may result from vascular damage. There is evidence that PAI-1 levels are related to genotype at a PAI-1 promoter polymorphism. Genotype at this 4G/5G polymorphism was determined in 160 NIDDM (90 males and 70 females) patients with (n = 38) or without (n = 122) clinical evidence of CAD. Levels of cholesterol were higher (6.5 vs 5.9 mM, p <0.01) and of PAI-1 tended to be higher (PAI-1 activity 23.0 vs 20.4 U/ml) with CAD. The frequency of the 4G/4G genotype was increased and the 5G/5G genotype decreased, in the group CAD compared to those without (p <0.05). These results suggest that possession of the 4G/4G PAI-1 promoter genotype is a risk factor for the development of CAD in subjects with NIDDM.

 

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