Increased Plasma Thrombin-Antithrombin III Complex Levels in Non-Insulin Dependent Diabetic Patients with Albuminuria Are Reduced by Ethyl Icosapentatenoate

Hiroyuki Shimizu; Ken-Ichi Ohtani; Yoshito Tanaka; Akira Fukatsu; Yutaka Uehara; Noriyuki Sato; Masatomo Mori

doi:10.1055/s-0038-1649917

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1995; 74(05): 1231-1234
DOI: 10.1055/s-0038-1649917

Original Article

Clinical Studies

Schattauer GmbH Stuttgart

Increased Plasma Thrombin-Antithrombin III Complex Levels in Non-Insulin Dependent Diabetic Patients with Albuminuria Are Reduced by Ethyl Icosapentatenoate

Authors

Hiroyuki Shimizu

The First Department of Internal Medicine, Gunma University School of Medicine, Maebashl Gunma, Japan
Ken-Ichi Ohtani

The First Department of Internal Medicine, Gunma University School of Medicine, Maebashl Gunma, Japan
Yoshito Tanaka

The First Department of Internal Medicine, Gunma University School of Medicine, Maebashl Gunma, Japan
Akira Fukatsu

The First Department of Internal Medicine, Gunma University School of Medicine, Maebashl Gunma, Japan
Yutaka Uehara

The First Department of Internal Medicine, Gunma University School of Medicine, Maebashl Gunma, Japan
Noriyuki Sato

The First Department of Internal Medicine, Gunma University School of Medicine, Maebashl Gunma, Japan
Masatomo Mori

The First Department of Internal Medicine, Gunma University School of Medicine, Maebashl Gunma, Japan

Abstract

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Summary

Hypercoagulability may increase the risk of cardiovascular disease (CVD) in diabetic patients with albuminuria. Plasma thrombin-antithrombin III complex (TAT) levels, representing a functional state of clotting system, were studied in one hundred and fifteen non-insulin- dependent diabetic (NIDDM) patients. The patients were divided into three groups according to the urine albumin index (UAI: mg/g Cr): Group A; UAI<30, Group B; 30<UAI<300, Group C; UAI>300. The effect of albuminuria on plasma TAT levels was significant (p<0.02). Ethyl icosapentatenoate (EPA: 1800 mg/day) for 4 weeks significantly (p<0.0005) decreased plasma TAT levels. These data indicate that the degree of diabetic albuminuria is related to plasma TAT levels in NIDDM patients and that treatment with EPA may reduce TAT levels and possibly therefore the rate of development of CVD in patients with NIDDM.

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References

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