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Thromb Haemost 1995; 74(05): 1252-1254
DOI: 10.1055/s-0038-1649921
Original Article
Clinical Studies
Schattauer GmbH Stuttgart

Variation of Phylioquinone (Vitamin K1) Concentrations in Hemodialysis Patients

Martin Kohlmeier
1   The Dept, of Nutrition, Schools of Medicine and Public Health, UNC, Chapel Hill, NC, USA
2   The Institut für Klin. Chem. Biochem., Freie Universität, Berlin, Germany
,
Jörg Saupe
3   The Dept. Internal Medicine III, Krankenhaus Moabit, Berlin, Germany
,
Hans-Joachim Drossel
4   The Zentrallabor, Urban Krankenhaus, Berlin, Germany
,
Martin J Shearer
5   The Haemophilia Centre, St. Thomas’ Hospital, London, UK
› Author Affiliations
Further Information

Publication History

Received 31 May 1995

Accepted after revision 07 August 1995

Publication Date:
10 July 2018 (online)

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Summary

Intra- and interindividual variation of phylloquinone (vitamin K1) concentrations was investigated by repeat analysis of serum from 28 hemodialysis patients with different apolipoprotein E genotypes. Phylloquinone concentrations ranged from 0.1 to 9.0 nM, with a mean of 1.08 nM (standard deviation 1.90 nM).

Most of the variation in serum phylloquinone concentrations was due to differences between patients; the ratio of intra-to interindividual variation was 0.17. Serum triglyceride concentrations and apoE genotype together accounted for 64% of interindividual variation; in contrast, only 6% of intraindividual variation could be attributed to differences in triglyceride concentrations.

The small residual variance implies that different phylloquinone consumption levels contributed relatively little to the variation of serum concentrations (<36% of interindividual variance). The results suggest that individual disposition is a more important determinant of serum phylloquinone concentrations than dietary phylloquinone intake.

 

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