Marathon Run III: Effects on Coagulation, Fibrinolysis, Platelet Aggregation and Serum Cortisol Levels

T Mandalaki; A Dessypris; C Louizou; C Panayotopoulou; C Dimitriadou

doi:10.1055/s-0038-1650010

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1980; 43(01): 049-052
DOI: 10.1055/s-0038-1650010

Original Article

Schattauer GmbH Stuttgart

Marathon Run III: Effects on Coagulation, Fibrinolysis, Platelet Aggregation and Serum Cortisol Levels

A 3-Year Study

T Mandalaki

The 2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi), Greece, and The Endocrine Research Laboratory, University of Helsinki, the Minerva Foundation Institute for Medical Research, Helsinki, Finland

,

A Dessypris

The 2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi), Greece, and The Endocrine Research Laboratory, University of Helsinki, the Minerva Foundation Institute for Medical Research, Helsinki, Finland

,

C Louizou

The 2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi), Greece, and The Endocrine Research Laboratory, University of Helsinki, the Minerva Foundation Institute for Medical Research, Helsinki, Finland

,

C Panayotopoulou

The 2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi), Greece, and The Endocrine Research Laboratory, University of Helsinki, the Minerva Foundation Institute for Medical Research, Helsinki, Finland

,

C Dimitriadou

The 2nd Regional Blood Transfusion Centre of Athens, Hospital Vassilefs Pavlos, Athens (Goudi), Greece, and The Endocrine Research Laboratory, University of Helsinki, the Minerva Foundation Institute for Medical Research, Helsinki, Finland

› Author Affiliations

Abstract

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Summary

Blood coagulation, fibrinolysis, platelet count-aggregation and Cortisol were assessed in 35 Finnish amateur runners aged 27 to 56 years (mean 40) and three aged 65, 67, and 82 who had run a non-competitive Marathon in 1975, 1976 and 1977 over the classical itinerary. After the run, in all 3 years, APTT showed shortening (p < 0.001); prothrombin time and plasma fibrinogen were not significantly altered; euglobulin lysis time was shorter (p < 0.001) and FDP increased (p < 0.001); PSPT became positive in all subjects, whereas the ethanol gelation test remained negative; no cryofibrinogen was detected. Platelet count and aggregation showed increase (p < 0.001) in 1975 (extreme heat, 25° C) but remained unaltered in 1976, 1977 (15–18° C). Cortisol levels were always significantly increased – more markedly in 1975. Women’s responses were similar to those of men. A possible correlation between physical fitness and the responses of haemostatic balance is suggested and the influence of weather is discussed.

Keywords

Marathon run - Coagulation - Fibrinolysis - Platelet aggregation - Stress - Cortisol - Weather conditions

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References

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