Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1980; 43(02): 090-094DOI: 10.1055/s-0038-1650024 Original Article Schattauer GmbH Stuttgart Clinical Trials in the Secondary Prevention of Myocardial Infarction and Stroke[*] Authors Author Affiliations P Armitage Department of Biomathematics, University of Oxford, U. K. Recommend Article Abstract PDF Download(opens in new window) Buy Article(opens in new window)Keywords KeywordsClinical trials - Randomization - Prognostic factors - Protocol departures - Factorial designs PDF (1373 kb) References References 1 Burkhardt R, Kienle G. Controlled clinical trials and medical ethics. Lancet 1978; 2: 1356-1359 2 Fincke M. Arzneimittelprüfung: Strafbare Versuchsmethoden. 1977 295: Heidelberg/Karlsruhe 3 Gehan EA, Freireich EJ. Non-randomized controls in cancer clinical trials. N Engl J Med 1974; 290: 198-203 4 Pocock SJ. Randomised clinical trials (letter). Br Med J 1977; 1: 1661 5 Peto R. Clinical trial methology. Biomedicine 1978; 28: 24-36 6 Chalmers RC, Matta RJ, Smith H, Kunzler AM. Evidence favoring the use of anticoagulants in the hospital phase of acute myocardial infarction. N Engl J Med 1977; 297: 1091-1096 7 Farewell VT, D'Angio GJ. A simulated study of historical controls using real data. (Submitted for publication, 1980.) 8 Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. II. Analysis and examples. Br J Cancer 1976; 34: 585-612 and 1977; 35 1 39 9 Pocock SJ, Armitage P, Galton DA G. The size of cancer clinical trials: an international survey. In Methods and Impact of Controlled Therapeutic Trials in Cancer Part I. UICC Technical Report Series 1978; 36: 5-32 Geneva, UICC 10 Staquet M, Sylvester R, Machin D, van Glabbeke M, de Grauwe G, Wennerholm A, Tyrrell J, Renard J, de Pauw M, Eeckhoudt D, Tyrrell J, Tagnon HJ. The E.O.R.T.C. Data Center. Eur J Cancer 1977; 13: 1455-1459 11 Boissel J-P, Leizorovicz A, Sanchini B, Biron A. Quality control and clinical trials. In Proceedings of Working Conference on Evaluation of Efficacy of Medical Action. ed. Gremy F, Alperovitch A. 1980. North Holland: 12 Cox DR. Regression models and life-tables. J R Statist Soc Ser B 1972; 34: 187-202 13 Gross AJ, Clark VA. Survival Distributions: Reliability Applications in the Biomedical Sciences. 1975. New York: Wiley: 14 Fields WS, Lemak NA, Frankowski RF, Hardy RJ. Controlled trial of aspirin in cerebral ischemia. Stroke 1977; 8: 301-316 15 Anturane Reinfarction Trial Research Group Sulfinpyrazone in the prevention of cardiac death after myocardial infarction. N Engl J Med 1978; 298: 289-295 16 Committee of Principal Investigators A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Br Heart J 1978; 40: 1069-1118 17 Canadian Cooperative Study Group A randomized trial of aspirin and sulfinpyrazone in threatened stroke. N Engl J Med 1978; 299: 53-59 18 Walpole H. Letter to H. Mann, 28 Jan. 1754 19 Lellouch J, Schwartz D. L'essai thérapeutique: éthique individuelle ou éthique collective?. Rev Inst Int Statist 1971; 39: 127-136 20 Armitage P. Sequential Medical Trials. 1975. 2nd ed. Oxford: Blackwell: 21 Coronary Drug Project Research Group Aspirin in coronary heart disease. J Chronic Dis 1976; 29: 625-642 22 McPherson K. Statistics: the problem of examining accumulating data more than once. N Engl J Med 1974; 290: 501-502 23 Canner PL. Monitoring treatment differences in long-term clinical trials. Biometrics 1977; 33: 603-615 24 Pocock SJ. Group sequential methods in the design and analysis of clinical trials. Biometrika 1977; 64: 191-199 25 European Coronary Surgery Study Group Coronary-artery bypass surgery in stable angina pectoris: survival at two years. Lancet 1979; 1: 889-893 26 Schwartz D, Lellouch J. Explanatory and pragmatic attitudes in therapeutic trials. J Chronic Dis 1967; 20: 637-648 27 Gent M, Sackett DL. The qualification and disqualification of patients and events in long-term cardiovascular clinical trials. In: The Challenge of Clinical Trials in Thrombosis. ed Verstraate M, Vermylen J, Roberts H. 1979. pp. 123-134 Stuttgart: Schattauer Verlag: 28 Doll R. The concurrent assessment of several treatments. In Controlled Clinical Trials ed. CIOMS. 1960. pp. 94-99 Oxford: Blackwell: 29 Wilson C, Pollock MR, Harris AD. Diet in the treatment of infective hepatitis: therapeutic trials of cysteine and variation of fat content. Lancet 1946; 1: 881-883
