Summary
Platelet aggregation is frequently impaired in myeloproliferative disorders (MPD).
The presence of spontaneous platelet aggregation (SPA) or alterations of the aggregation
pattern after ADP, epinephrine and collagen have been a frequent feature in the series
of 52 patients here presented. The occurrence of SPA was not related to the findings
obtained with the aggregating agents or to the number of circulating platelets. The
aggregation results did not correlate with the number of megathrombocytes.
The presence of platelet abnormalities, not completely corrected after busulfan therapy,
and the increased size of platelets should aid in diagnosis of myeloproliferative
disorders.
Keywords
Platelet aggregation - Myeloproliferative disorders - Platelet size - Platelet function
after busulfan
