Thromb Haemost 1980; 43(02): 133-136
DOI: 10.1055/s-0038-1650034
Original Article
Schattauer GmbH Stuttgart

Heterogeneity of the "Classical" Antithrombin III Deficiency

Géza Sas
The Postgraduate Medical School, First Department of Medicine, Budapest, Hungary
,
Iván Petö
The Postgraduate Medical School, First Department of Medicine, Budapest, Hungary
,
Denes Bánhegyi
The Postgraduate Medical School, First Department of Medicine, Budapest, Hungary
,
György Blaskó
The Postgraduate Medical School, First Department of Medicine, Budapest, Hungary
,
Gyula Domján
The Postgraduate Medical School, First Department of Medicine, Budapest, Hungary
› Author Affiliations
Further Information

Publication History

Received 31 January 1980

Accepted 07 March 1980

Publication Date:
13 July 2018 (online)

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Summary

We investigated two thrombophilia families with the "classical" type of antithrombin III deficiency, i.e., with a low antithrombin III level measured both by immunochemical and functional methods.

We obtained different antithrombin III patterns in the plasma of the affected members of the two families with the modified two dimensional immunoelectrophoresis method (heparin in agarose). In one family, the electrophoretic mobility of the antithrombin III is identical with that of normal antithrombin III. In the other, the antithrombin III displayed a decreased electrophoretic mobility in the heparinized agarose gel. The relatively low affinity of this antithrombin III to heparin could be directly proved by the heparin-agarose affinity chromatography, too. These two different antithrombin III patterns were observed by other investigators at different families as well.

On the basis of our simultaneous observations of these two families we propose a classification of the inherited congenital antithrombin III deficiencies.