AB0 Blood Groups and Coronary Heart Disease (CHD)

Jan Erikssen; Erik Thaulow; Helge Stormorken; Ole Brendemoen; Arvid Hellem

doi:10.1055/s-0038-1650035

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1980; 43(02): 137-140
DOI: 10.1055/s-0038-1650035

Original Article

Schattauer GmbH Stuttgart

AB0 Blood Groups and Coronary Heart Disease (CHD)

A Study in Subjects with Severe and Latent CHD

Authors

Jan Erikssen

^*The Cardiological Section, Medical Dept. B, Rikshospitalet, Oslo, Norway
Erik Thaulow

^*The Cardiological Section, Medical Dept. B, Rikshospitalet, Oslo, Norway
Helge Stormorken

^**The Institute for Thrombosis Research, Rikshospitalet, Oslo, Norway
Ole Brendemoen

^***The Institute of Blood Group and Tissue Typing, Rikshospitalet, Oslo, Norway
Arvid Hellem

^**The Institute for Thrombosis Research, Rikshospitalet, Oslo, Norway

Abstract

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Summary

The view based on epidemiological and laboratory data that blood group A subjects (=A) have clinically significant higher thrombotic potential than blood group 0 subjects (= O), is supported by the present finding of a significantly higher platelet retention in A than 0.

The completely normal ABO distribution found among 71 cases of proven latent CHD, and the disproportionate excess of 0 vs. A in a consecutive series of 191 coronary artery bypass candidates apparently conflict with epidemiological data indicating a higher risk of achieving CHD in A than 0. The conflict may be solved by suggesting

a) that the »thrombotic proneness« in A compared with 0 causes a poorer prognosis in CHD among the former, leaving a disproportionate excess of 0 among longterm CHD survivors, and b) that AB0-related factors have had an insignificant, independent impact on the evolution of preclinical coronary artery disease in our 71 men with latent CHD.

Keywords

AB0-related coronary risk factors - Platelet retention - Coagulation factors - Blood group A and arterial thrombosis

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References

References
1 Korsan-Bengtsen K, Wilhelmsen L, Nilsson LÅ, Tibblin G. Blood coagulation and fibrinolysis in relation to AB0, Rh, MN and Duffy blood groups in a random population sample of men aged 54 years. Thromb Res 1: 549 1972;
2 Fagerhol M, Abildgaard U, Kornstad L. Antithrombin III concentration and AB0 blood groups. Lancet 2: 664 1971;
3 Stormorken H, Erikssen J. Plasma antithrombin III and factor VIII antigen in relation to angiographic findings, angina and blood groups in middle-aged men. Thromb Haemost 38: 874 1977;
4 Mourant AE, Kopeć AC, Domaniewska-Sobczak K. Blood groups and diseases. A study of associations of diseases with blood groups and other polymorhisms. Oxford Medical Publications, Oxford University Press: 1978
5 Erikssen J, Enge I, Forfang K, Storstein O. False positive diagnostic tests and coronary angiographic findings in 105 presumably healthy males. Circulation 54: 371 1976;
6 Erikssen J, Rasmussen K, Forgang K, Storstein O. Exercise ECG and case history in the diagnosis of latent coronary heart disease among presumably healthy middle-aged men. Eur J Cardiol 5/6: 463 1977;
7 Judkins MP. Percutaneous transfemoral selective coronary angiography. Radiol Clin N Am 6: 467 1968;
8 Hartmann O, Lundevall J. Blood group distribution in Norway with special regard to MN and 0A₁A₂B. Der Norske Vitenskapsakademi I, Mat Nat V, klasse 2 1944
9 Hellem A. The adhesiveness of human blood platelets in vitro. Scand J Clin Lab Invest 1960; 12 Suppl 51
10 Hellem A. Platelet adhesiveness in von Willebrand’s disease. A study with a new modification of the glass bead filter method. Scan J Haematol 7: 374 1970;
11 Erikssen J, Skrede S. Serum lipids and latent coronary insufficiency. Scand J Clin Lab Invest 37: 243 1977;
12 Stormorken H, Erikssen J. Unpublished data
13 Langman MJ S, Doll R. AB0 blood groups and secretor status in relation to clinical characteristics of peptic ulcers. Gut 6: 270 1965;
14 Vessey MP. The epidemiology of venous thromboembolism. In: Recent Advances in Thrombosis. Ed: Poller L. Churchill-Livingstone, London: p. 39-58 1973
15 Slone D, Gaetano LF, Lipworth L, et al. Computer analysis of epidemiologic data on effect of drugs on hospital patients. Public Health Rep 84: 39 1969;
16 Jick H, Slone D, Westerholm B, et al. Venous thromboembolic disease and AB0 blood type. A cooperative study. Lancet 539 1969;
17 Gertler MM, White PD. Coronary heart disease in young adults. Harvard University Press, Cambridge, Massachusetts: 1954
18 Bronte-Stewart B, Botha MC, Kurt LH. AB0-blood groups in relation to ischaemic heart disease. Br Med J I: 1646 1962;
19 Allan TM, Dawson AA. AB0 blood groups and ischaemic heart disease in men. Br heart J 30: 377 1968;
20 Mollison PL. Blood transfusion in clinical medicine. 5th Ed Blackwell Scientific publications: pp 159-164 1972
21 Kingsbury KJ. Relation of AB0 blood groups to atherosclerosis. Lancet I: 199 1971;
22 Oliver MF, Geizerova H, Cummings RA, Heady JA. Serum cholesterol and AB0 and Rhesus blood groups. Lancet 2: 605 1969;
23 Langmann MJ S, Elwood PC, Foote J, Ryrie DR. AB0 and Lewis blood groups and serum cholesterol. Lancet 2: 607 1969;
24 Hellem A, Hovig T. Unpublished data
25 Fuster V, Bowie EJ W. The von Willebrand pig as a model for atherosclerosis research. Thromb Heamost 39: 322 1978;
26 Harker LA, Ross R, Schlichter SJ, Scott CR. Homocysteine-induced atherosclerosis: The role of endothelial cell injury and platelet response to its genesis. J Clin Invest 58: 731 1976;
27 Harker LA, Ross R, Glomset J. The role of endothelial injury and platelet response in atherogenesis. Thromb Haemost 39: 312 1978;
28 Ross R, Glomset J. The pathogenesis of atherosclerosis. New Engl J Med 295: 369 1976;
29 Pearson TA, Dillmann J, Solez K, Heptinstall RH. Monoclonal characteristics of organizing arterial thrombi. Significance in the origin and growth of human arteriosclerotic plaques. Lancet I: 7 1979;
30 Fass DN, Didisheim P, Lewis JC, Grabouski ET. Adhesion of porcine von Willebrand (vWd) platelets. (Abstract), Circulation Suppl 54 II 1976;