AB0 Blood Groups and Coronary Heart Disease (CHD)

Jan Erikssen; Erik Thaulow; Helge Stormorken; Ole Brendemoen; Arvid Hellem

doi:10.1055/s-0038-1650035

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1980; 43(02): 137-140
DOI: 10.1055/s-0038-1650035

Original Article

Schattauer GmbH Stuttgart

AB0 Blood Groups and Coronary Heart Disease (CHD)

A Study in Subjects with Severe and Latent CHD

Jan Erikssen

^*The Cardiological Section, Medical Dept. B, Rikshospitalet, Oslo, Norway

,

Erik Thaulow

^*The Cardiological Section, Medical Dept. B, Rikshospitalet, Oslo, Norway

,

Helge Stormorken

^**The Institute for Thrombosis Research, Rikshospitalet, Oslo, Norway

,

Ole Brendemoen

^***The Institute of Blood Group and Tissue Typing, Rikshospitalet, Oslo, Norway

,

Arvid Hellem

^**The Institute for Thrombosis Research, Rikshospitalet, Oslo, Norway

› Institutsangaben

Abstract

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Summary

The view based on epidemiological and laboratory data that blood group A subjects (=A) have clinically significant higher thrombotic potential than blood group 0 subjects (= O), is supported by the present finding of a significantly higher platelet retention in A than 0.

The completely normal ABO distribution found among 71 cases of proven latent CHD, and the disproportionate excess of 0 vs. A in a consecutive series of 191 coronary artery bypass candidates apparently conflict with epidemiological data indicating a higher risk of achieving CHD in A than 0. The conflict may be solved by suggesting

a) that the »thrombotic proneness« in A compared with 0 causes a poorer prognosis in CHD among the former, leaving a disproportionate excess of 0 among longterm CHD survivors, and b) that AB0-related factors have had an insignificant, independent impact on the evolution of preclinical coronary artery disease in our 71 men with latent CHD.

Keywords

AB0-related coronary risk factors - Platelet retention - Coagulation factors - Blood group A and arterial thrombosis

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Referenzen

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