Studies of Aggregation and Thromboxane B2 Synthesis in Avian Thrombocytes: Comparison between Atherosclerosis-Susceptible and Resistant Breeds

M T R Subbiah; R Yunker; L Gallon

doi:10.1055/s-0038-1650048

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1980; 43(03): 189-191
DOI: 10.1055/s-0038-1650048

Original Article

Schattauer GmbH Stuttgart

Studies of Aggregation and Thromboxane B₂ Synthesis in Avian Thrombocytes: Comparison between Atherosclerosis-Susceptible and Resistant Breeds

M T R Subbiah

The Departments of Medicine (LIPID Research Center) and Pathology, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A.

,

R Yunker

The Departments of Medicine (LIPID Research Center) and Pathology, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A.

,

L Gallon

The Departments of Medicine (LIPID Research Center) and Pathology, University of Cincinnati Medical Center, Cincinnati, Ohio, U.S.A.

› Author Affiliations

Abstract

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Summary

Comparison of thrombocyte aggregation in response to arachidonic acid and synthesis of prostaglandins from C¹⁴-arachidonic acid by thrombocytes was made between atherosclerosis-susceptible White Carneau and atherosclerosis-resistant Show Racer Pigeons. Contrary to the expectations, thrombocytes from atherosclerosis-susceptible pigeons were a) less sensitive to arachidonic acid induced aggregation and b) synthesized less thromboxane B₂ (stable product of proaggregatory thromboxane A₂) from C¹⁴-arachidonic acid. Analysis of fatty acid composition of thrombocyte phospholipids indicated a higher concentration of arachidonic acid in White Carneau Pigeons. These results suggest that thrombocytes from atherosclerosis-susceptible pigeons are altered early and as a defense mechanism display less responsiveness towards aggregation.

Keywords

Avian thrombocytes - Thromboxane B₂ - Thrombocyte aggregation - Atherosclerosis-susceptibility

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References

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