Thromb Haemost 1981; 45(01): 001-005
DOI: 10.1055/s-0038-1650118
Original Article
Schattauer GmbH Stuttgart

Some Characteristics of Mouse Platelet Aggregation and a Comparison of the Activity of a Range of Compounds in Mouse and Human Platelet-Rich Plasma in Vitro

Barbara Nunn
Beecham Pharmaceuticals Research Division, Animal Health Research Centre, Walton Oaks, Tadworth, Surrey, U.K
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Publikationsverlauf

Received 04. April 1980

Accepted 18. Oktober 1980

Publikationsdatum:
04. Juli 2018 (online)

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Summary

Collagen-induced platelet aggregation in mouse citrated platelet-rich plasma (PRP) was associated with 5-hydroxytryptamine (5-HT) release and degranulation. Adenosine 5’-diphosphate (ADP) induced monophasic and reversible aggregation with no degranulation. Mouse platelets gave no response to adrenaline but changed shape and sometimes aggregated in response to 5-HT. Both amines potentiated the effect of ADP. The respective potencies of prostaglandin E1, papaverine, VK 774, BL 3459 and adenosine as inhibitors of ADP-induced aggregation were similar in mouse and human PRP. Although ticlopidine had similar activity in the two species, aspirin and flurbiprofen were considerably less potent in mouse than human PRP as inhibitors of collagen-induced aggregation. It is suggested that collagen-induced aggregation of mouse platelets in vitro occurs by a mechanism largely independent of arachidonic acid metabolites.