Thromb Haemost 1981; 45(02): 146-149
DOI: 10.1055/s-0038-1650152
Original Article
Schattauer GmbH Stuttgart

Heparin Excretion in Intact and Hepatectomized Rats

Ray Losito
The Department of Medicine, Centre Hospitalier Universitaire, Sherbrooke, Québec, Canada
,
Harry Gattiker
The Department of Medicine, Centre Hospitalier Universitaire, Sherbrooke, Québec, Canada
,
Ginette Bilodeau
The Department of Medicine, Centre Hospitalier Universitaire, Sherbrooke, Québec, Canada
› Institutsangaben
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Publikationsverlauf

Received 16. Oktober 1980

Accepted 22. Januar 1981

Publikationsdatum:
05. Juli 2018 (online)

Summary

Metabolism and kinetics of 3H-heparin were compared in intact and hepatectomized rats. Rats were divided into three groups: 1) intact rats with biliary fistulas and cystostomies 2) intact rats with only cystostomies and 3) hepatectomized rats with cystostomies. Radioactivity in blood, bile and urine besides anticoagulant activity in blood and urine were examined. In addition, column chromatography of urine was used to isolate possible metabolites. Seventy percent and 80% of the radioactive dose was found in the urine of intact rats at 24 hr and 48 hr. Close to 5% of the radioactivity was found in bile or rats with a biliary fistula after 48 hr. The APTT declined to near normal values at 1 hr whether rats had a biliary fistula or not. In contrast, only 25 % of the radioactivity could be excreted into the urine of hepatectomized rats in 24 hr; the APTT did not decline as fast and at 5 hr, it was still 100 seconds. Only one radioactive component could be isolated on chromatography from all urines of these animals and appears to be similar to the original heparin. Thus, the liver has an important role to play in regulating the anticoagulant effects and excretion of heparin.