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DOI: 10.1055/s-0038-1650154
Binding of 99mTc Plasminogen on Fibrin
Publication History
Received 28 November 1980
Accepted 22 January 1981
Publication Date:
05 July 2018 (online)


Summary
Binding of plasminogen to fibrin was studied in vitro and in vivo using 99mTc Glu- and Lys-plasminogen.
Binding of Glu-plasminogen on the clot was not observed in vitro, and in vivo in the dog.
Conversely, the binding of Lys-plasminogen to fibrin displays a linear relationship to the concentration of Lys-plasminogen, up to doses exceeding equimolarity; thus suggesting the existence of several Lys-plasminogen binding sites on fibrin. Binding levels were identical, regardless of whether plasminogen was incubated in normal plasma or in plasma devoid of antiplasmin. In the dog, Lys-plasminogen bound specifically to the clot, however, clot sites could not be localized by scintigraphy in the dog or in man.