Hemostasis Abnormalities in Patients with Vascular Dementia and Alzheimer’s Disease

D Mari; L Parnetti; R Coppola; B Bottasso; G P Reboldi; U Senin; P M Mannucci

doi:10.1055/s-0038-1650246

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1996; 75(02): 216-218
DOI: 10.1055/s-0038-1650246

Original Article

Schattauer GmbH Stuttgart

Hemostasis Abnormalities in Patients with Vascular Dementia and Alzheimer’s Disease

D Mari

The Geriatrics Unit, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milan; and Gerontology and Geriatrics, University of Perugia, Italy

,

L Parnetti

The Geriatrics Unit, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milan; and Gerontology and Geriatrics, University of Perugia, Italy

,

R Coppola

The Geriatrics Unit, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milan; and Gerontology and Geriatrics, University of Perugia, Italy

,

B Bottasso

The Geriatrics Unit, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milan; and Gerontology and Geriatrics, University of Perugia, Italy

,

G P Reboldi

The Geriatrics Unit, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milan; and Gerontology and Geriatrics, University of Perugia, Italy

,

U Senin

The Geriatrics Unit, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milan; and Gerontology and Geriatrics, University of Perugia, Italy

,

P M Mannucci

The Geriatrics Unit, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Institute of Internal Medicine, IRCCS Maggiore Hospital and University of Milan; and Gerontology and Geriatrics, University of Perugia, Italy

› Author Affiliations

Abstract

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Summary

Since it has not been established to what extent abnormalities of hemostasis contribute to the occurrence and development of dementia, selected measurements of coagulation and fibrinolysis were obtained in elderly patients with Alzheimer’s disease (n = 22) or vascular dementia (n = 29), compared with healthy individuals in the same age range (n = 61). Hemostasis abnormalities were more frequent and marked in vascular dementia, being expressed as significant increases of plasminogen activator inhibitor type 1, von Willebrand factor, D-dimer. and activated factor VII. However, some hemostasis measurements (von Willebrand factor, activated factor VII) were abnormally high also in the patients with Alzheimer’s disease, a condition in which vascular damage is not considered to play a major pathogenetic role. It could not be established in this study whether or not these hemostatic abnormalities play a causal role in the pathogenesis of dementia, or whether they are secondary to inflammation and chronic vascular disease. Nevertheless, their presence may contribute to aggravating vascular disease.

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References

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