Platelet Density and Size in Inflammatory Bowel Disease

Summary

Objective: The present study investigates platelet density and mean platelet volume (MPV) in active inflammatory bowel disease (IBD).

Experimental protocol: 27 patients with IBD (18 ulcerative colitis and 9 Crohn’s disease) were compared to 12 healthy volunteers. 18 subjects had active disease. Platelet counts and mean platelet volume (MPV) were determined. Thereafter, platelets were separated according to density on a linear preformed Percoll gradient. A computerized device was employed for scanning transmission variations and thus the platelet distribution in the gradient and the platelet peak were identified.

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