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Thromb Haemost 1996; 75(05): 778-781
DOI: 10.1055/s-0038-1650366
Original Article
Schattauer GmbH Stuttgart

Fibrinogen and Factor Vllag in Healthy Adolescents: The Floren-teen (Florence Teenager) Study

Domenico Prisco
1   The Istituto di Clinica Medica Generale e Cardiologia University of Florence
,
Sandra Fedi
1   The Istituto di Clinica Medica Generale e Cardiologia University of Florence
,
Tamara Brunelli
1   The Istituto di Clinica Medica Generale e Cardiologia University of Florence
,
Anna Paola Cellai
1   The Istituto di Clinica Medica Generale e Cardiologia University of Florence
,
Mohamed Isse Hagi
1   The Istituto di Clinica Medica Generale e Cardiologia University of Florence
,
Roberto Gianni
2   Nuovo Ospedale San Giovanni di Dio, Florence, Italy
,
Emilio Santoro
2   Nuovo Ospedale San Giovanni di Dio, Florence, Italy
,
Carlo Cappelletti
2   Nuovo Ospedale San Giovanni di Dio, Florence, Italy
,
Guglielmina Pepe
1   The Istituto di Clinica Medica Generale e Cardiologia University of Florence
,
Gian Franco Gensini
1   The Istituto di Clinica Medica Generale e Cardiologia University of Florence
,
Rosanna Abbate
1   The Istituto di Clinica Medica Generale e Cardiologia University of Florence
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Publikationsverlauf

Received 17. Juli 1995

Accepted after resubmission 06. Februar 1996

Publikationsdatum:
10. Juli 2018 (online)

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Summary

At least five studies based on more than twenty thousand healthy subjects indicated that fibrinogen is an independent risk factor for cardiovascular events; less clear-cut is the relation between factor VII and risk for arterial thrombotic disorders, which was demonstrated in two of the three studies investigating this association. However, no study has investigated the behaviour of fibrinogen and factor VII in an adolescent population. In a study of Preventive Medicine and Education Program, fibrinogen (clotting method) and factor Vllag (ELISA), in addition to other metabolic parameters, life-style and familial history, were investigated in 451 students (313 females and 138 males, age 15-17 years) from two high schools of Florence. Fibrinogen levels were significantly higher in women than in men, whereas factor Vllag levels did not significantly differ. Both fibrinogen and factor Vllag significantly correlated with total cholesterol (p <0.05) while only fibrinogen correlated with body mass index (p <0.01). Factor Vllag was significantly correlated with systolic blood pressure (p <0.001). This study provides information on coagulation risk factors in a population of adolescents which may be of importance in planning coronary heart disease prevention programs.

 

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