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Thromb Haemost 1996; 75(05): 833-837
DOI: 10.1055/s-0038-1650375
Original Article
Schattauer GmbH Stuttgart

Enhanced Platelet Aggregability under High Shear Stress after Treadmill Exercise in Patients with Effort Angina

Junya Tokuue
1   The Department of Medicine and Gerontology, Tokyo, Japan
,
Junichi Hayashi
1   The Department of Medicine and Gerontology, Tokyo, Japan
,
Yoshiya Hata
1   The Department of Medicine and Gerontology, Tokyo, Japan
,
Kazuhiko Nakahara
2   The Department of Clinical Pathology, Kyorin University, Tokyo, Japan
,
Yasuo Ikeda
3   The Division of Hematology, Department of Medicine, Keio University, Tokyo, Japan
› Author Affiliations
Further Information

Publication History

Received 25 July 1995

Accepted after resubmission 22 January 1996

Publication Date:
10 July 2018 (online)

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Summary

Platelet activation induced by shear forces occurring in a stenosed coronary artery is one of the mechanisms of coronary thrombosis. We evaluated the shear-induced platelet aggregation (SIPA) dynamics in patients with effort angina during treadmill exercise. SIPA was measured by a rotational cone-plate aggregometer. SIPA was markedly increased by exercise from 71.2 ± 8.9% to 81.9 ± 7.6% (p <0.01) in the patient group. Although epinephrine concentrations were elevated, its rate of increase was not correlated with that of SIPA. Yohimbine partially inhibited the exercise-induced increase in SIPA. In contrast, a significant correlation between the changing rate of plasma von Willebrand factor (vWF) larger multimers and that of SIPA (r = 0.74, p <0.05) was observed. Exercise-augmented SIPA is probably dependent on an increase in vWF larger multimers rather than platelet alpha2-receptor activation. Prevention of the interaction between vWF and its platelet receptors may play some role in decreasing the risk of coronary thrombosis during exercise.

 

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