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Thromb Haemost 1996; 76(01): 094-098
DOI: 10.1055/s-0038-1650529
Original Article
Schattauer GmbH Stuttgart

The Antiaggregating and Antithrombotic Activity of Ticlopidine Is Potentiated by Aspirin in the Rat

J M Herbert
The Sanofi Recherche, Haemobiology Research Department, Toulouse, France
,
A Bernat
The Sanofi Recherche, Haemobiology Research Department, Toulouse, France
,
M Samama
1   Laboratoire Central d’hématologie, Hôtel-Dieu, Paris, France
,
J P Maffrand
The Sanofi Recherche, Haemobiology Research Department, Toulouse, France
› Author Affiliations
Further Information

Publication History

Received 23 October 1995

Accepted after resubmission 27 March 1996

Publication Date:
10 July 2018 (online)

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Summary

Since ticlopidine specifically inhibits ADP-induced platelet aggregation without affecting prostaglandin metabolism, it seemed interesting to evaluate the effect of aspirin with regard to the antithrombotic efficacy of ticlopidine. Ticlopidine was administered orally to rats alone or in combination with aspirin and the efficacy of the association was determined in several experimental models. A synergistic effect of the ticlopidine/aspirin association was demonstrated with regard to ADP- and collagen-induced platelet aggregation measured ex vivo but also in several experimental thrombosis models including silk thread-induced thrombosis in an arteriovenous shunt, wire coil-induced thrombosis and 111In-labelled platelet deposition on the subendothelium following air drying injury of the rat carotid artery. Similar results were obtained with regard to myointimal proliferation following air-induced injury of the rat carotid artery which occurred as a consequence of vascular injury. The ticlopidine/aspirin combination showed only additive-type effects on bleeding time prolongation induced by tail transection in the rat.

 

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