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Thromb Haemost 1996; 76(02): 187-189
DOI: 10.1055/s-0038-1650551
Original Article
Schattauer GmbH Stuttgart

Deep Venous Thrombosis and Lupus Anticoagulant

A Case-control Study
Paolo Simioni
The Institute of Medical Semeiotics, University Hospital of Padua, Padua, Italy
,
Paolo Prandoni
The Institute of Medical Semeiotics, University Hospital of Padua, Padua, Italy
,
Ezio Zanon
The Institute of Medical Semeiotics, University Hospital of Padua, Padua, Italy
,
Maria A Saracino
The Institute of Medical Semeiotics, University Hospital of Padua, Padua, Italy
,
Alberta Scudeller
The Institute of Medical Semeiotics, University Hospital of Padua, Padua, Italy
,
Sabina Villalta
The Institute of Medical Semeiotics, University Hospital of Padua, Padua, Italy
,
Luigi Scarano
The Institute of Medical Semeiotics, University Hospital of Padua, Padua, Italy
,
Bruno Girolami
The Institute of Medical Semeiotics, University Hospital of Padua, Padua, Italy
,
Lino Benedetti
1   Second Service of Radiology, University Hospital of Padua, Padua, Italy
,
Antonio Girolami
The Institute of Medical Semeiotics, University Hospital of Padua, Padua, Italy
› Author Affiliations
Further Information

Publication History

Received 18 January 1996

Accepted after resubmission 02 May 1996

Publication Date:
26 July 2018 (online)

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Summary

Background. A definite evidence in favour of an association of deep-vein thrombosis (DVT) with lupus anticoagulant (LA) in patients free from systemic lupus erythematosus is still lacking.

Methods. In a case-control study, LA was determined in 176 consecutive outpatients who underwent phlebography because of the first episode of clinically suspected DVT of lower limbs. The association between DVT and LA was described using odds ratios (OR).

Results. Contrast venography confirmed the clinical suspicion in 59 patients (33.5%). LA was detected in 5 of the 59 patients with DVT (8.5%), and in none of the 117 subjects with normal venogram (P = 0.007). The OR for having an acute DVT in patients with LA was 10.7 (95% CI: 1.2-94.2).

Conclusions. LA is significantly associated with DVT in symptomatic patients. Further studies are needed to establish the clinical implications of this association.

 

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