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Thromb Haemost 1996; 76(02): 245-247
DOI: 10.1055/s-0038-1650562
Original Article
Schattauer GmbH Stuttgart

The Largest Isoform of Platelet Membrane Glycoprotein Iba Is Commonly Distributed in Eastern Asian Populations

Fumihiro Ishida
1   The Second Department of Internal Medicine, Shinshu University School of Medicine, Shounan Hospital, Japan
4   Matsumoto, Japan
,
Kenichi Furihata
2   Department of Laboratory Medicine, Shinshu University School of Medicine, Shounan Hospital, Japan
,
Kimitaka Ishida
3   First Department of Surgery, Shinshu University School of Medicine, Shounan Hospital, Japan
,
Hiroshi Kodaira
1   The Second Department of Internal Medicine, Shinshu University School of Medicine, Shounan Hospital, Japan
,
Kyou Sup Han
5   Department of Clinical Pathology, Seoul National University College of Medicine, Seoul, Korea
,
Liu Da-Zhuang
6   Shanghai Blood Center, Shanghai, China
,
Kiyoshi Kitano
1   The Second Department of Internal Medicine, Shinshu University School of Medicine, Shounan Hospital, Japan
,
Kendo Kiyosawa
1   The Second Department of Internal Medicine, Shinshu University School of Medicine, Shounan Hospital, Japan
› Author Affiliations
Further Information

Publication History

Received 09 January 1996

Accepted after resubmission 02 May 1996

Publication Date:
10 July 2018 (online)

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Summary

Platelet membrane glycoprotein Iba has at least two polymorphisms which affect phenotype. One is the dimorphism at codon 145, and the other is a molecular weight polymorphism due to variable numbers of tandem repeats (TR) in the macroglycopeptide region. These two polymorphisms are in linkage disequilibrium. The frequencies of these polymorphisms differ considerably depending on race, and the largest variant with four TR is almost exclusively present in the Japanese population. We examined the genotypes of HPA-2 and TR polymorphism in three different races from Eastern Asia; the Japanese (n = 103), Korean (n = 101) and Chinese population (n = 177). The gene frequency of HPA-2 differed significantly among these three populations. Among HPA-2b-positive individuals, the A isoform with four TR and B with three TR were present in all three populations and A dominated over B. Individuals homozygous for the A isoform were found in both Japanese and Korean populations. These findings indicate that the largest haplotype is common in the Eastern Asian region.

 

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