Haemostatic Parameters and Lifestyle Factors in Elderly Men in Italy and The Netherlands

Fransje C H Bijnen; Edith J M Feskens; Simona Giampaoli; Alessandro Menotti; Flaminio Fidanza; Gerard Hornstra; Carl J Caspersen; Willem L Mosterd; Daan Kromhout

doi:10.1055/s-0038-1650592

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1996; 76(03): 411-416
DOI: 10.1055/s-0038-1650592

Original Article

Schattauer GmbH Stuttgart

Haemostatic Parameters and Lifestyle Factors in Elderly Men in Italy and The Netherlands

Fransje C H Bijnen

¹The Department of Medical Physiology and Sports Medicine, Utrecht University, Utrecht, The Netherlands

²The Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands

,

Edith J M Feskens

²The Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands

,

Simona Giampaoli

³The Laboratory of Epidemiology and Biostatistics, National Institute of Health, Rome, Italy

,

Alessandro Menotti

⁴The Division of Epidemiology, University of Minnesota, Minneapolis MN, USA

,

Flaminio Fidanza

⁵The Institute of Food Sciences and Nutrition, University of Perugia, Perugia, Italy

,

Gerard Hornstra

⁶Department of Human Biology, University of Limburg, Maastricht, The Netherlands

,

Carl J Caspersen

⁷Cardiovascular Health Studies Branch, Division of Chronic Disease Control and Community Intervention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control, Atlanta, Georgia, USA

,

Willem L Mosterd

¹The Department of Medical Physiology and Sports Medicine, Utrecht University, Utrecht, The Netherlands

,

Daan Kromhout

²The Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands

› Author Affiliations

Abstract

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Summary

The association between plasma fibrinogen, factor VII, factor X, activated partial thromboplastin time, antithrombin III and the lifestyle factors cigarette smoking, alcohol use, fat intake and physical activity was assessed in 802 men aged 70-90 years in Zutphen (The Netherlands), Montegiorgio and Crevalcore (Italy).

Smoking was positively associated with fibrinogen, also after adjustment for other lifestyle factors, age, use of anticoagulants and aspirin like drugs, body mass index, and history of myocardial infarction. Alcohol use was associated with increased levels of factor X and decreased levels of antithrombin III. Fat intake was positively associated with antithrombin III. Between cohorts, considerable differences were observed in levels of haemostatic parameters and the lifestyle factors. Compared to the mediterranean cohorts the Zutphen cohort showed the highest levels of fibrinogen and factor VII. Differences in lifestyle factors could, however, not explain differences between cohorts in levels of any of the haemostatic parameters, despite the observed associations between lifestyle factors and haemostatic parameters.

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References

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