The Animal Models for Hemorrhage and Thrombosis in the Neonate

C Thomas Kisker

doi:10.1055/s-0038-1651075

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1987; 57(01): 118-122
DOI: 10.1055/s-0038-1651075

International Committee Communications

Schattauer GmbH Stuttgart

The Animal Models for Hemorrhage and Thrombosis in the Neonate

C Thomas Kisker

Presented in Part at the Subcommittee on Neonatal Hemostasis of the International Committee on Thrombosis and Hemostasis, Miami, Florida, USA, November, 1984

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Abstract

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Summary

Animal models have added significantly to our understanding of adult hemorrhagic and thrombotic diseases. Few models, however, have been developed for studies of the hemostatic disorders in the fetus and newborn. This report reviews the current information on animal models of fetal and neonatal hemostasis. The requirements of a relevant model are addressed and previous studies using fetal and neonatal animal models are reviewed. A recommendation of a single animal for all studies of fetal and neonatal hemostasis is not possible. However, the lamb has been the most frequently studied and appears to provide relevant information regarding normal development and the factors which may adversely influence hemostasis in the fetus and newborn.

Keywords

Animal models - Hemorrhage - Thrombosis - Neonate

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Referenzen

References
1 Bernard C. An Introduction to the Study of Experimental Medicine. (Trans. by H C Greene), Henry Schoman 1927
2 Mustard JF, Secord D, Hoeksema TD, Downie HG, Rowsell HC. Canine Factor VII Deficiency. Br J Haematol 1962; 8: 43
3 Graham JB, Brinkhous KM, Dodds WJ. Canine and Equine Hemophilia. In: Homebook of Hemophilia. Brinkhous KM, Hemker HC. (eds). Excerpta Media; Amsterdam: 1975: 119-139
4 Mustard JF, Rosell HC, Robinson GA, Hoeksema TD, Downie HG. Canine Haemophilia B (Christmas Disease). Br J Haematol 1960; 6: 259
5 Dodds WJ. Canine Factor X (Steward-Prower Factor) Deficiency. J Lab Clin Med 1973; 82: 560
6 Kociba GJ, Ratnoff OD, Loeb WF, Wall RL, Heider LE. Bovine Plasma Thromboplastin Antecedent (Factor XI) Deficiency. J Lab Clin Med 1969; 74: 37
7 Dodds WJ, Koll JE. Canine Factor XI (Plasma Thromboplastin Antecedent) Deficiency. J Lab Clin Med 1971; 78: 746
8 Bogort R, Mohrer ME. The Inheritance of a Hemophilia-Like Condition in Swine. J Hered 1942; 33: 59-64
9 Bowie E JW, Owen CA, Zoliman PE, Thompson Jr JH, Fass DN. Tests of Hemostasis in Swine: Normal Values in Pigs Affected with von Willebrand’s Disease. Am J Vet Res 1973; 34: 1405-1407
10 Breukink JH, Hart HC, Arkel C, Velders NA, Watering CC. Congenital Afibrinogenemia in Goats. Zentralbl Veterinaer Med Reihe A 1972; 19: 661
11 Dam H. Antihemorrhagic Vitamin of the Chick: Occurrence and Chemical Nature. Nature 1935; 135: 625
12 Stenflo J, Suttie JW. Vitamin K-Dependent Formation of Carboxyglutamic Acid. Ann Rev Biochem 1977; 46: 157-172
13 Saranelli G. Experimental Cholera. Am Inst Pasteor Paris 1924; 38: 11-72
14 Schwartzman G. Phenomenon of Local Tissue Reactivity and Its Immunological, Pathological, and Clinical Consequences. Hoeber; New York: 1937. p 146
15 Nafstad I. The Vitamin-E-Deficiency Syndrome in Pigs. Vet Pathol 1971; 8: 239-255
16 Freak MJ. Symposium on Thrombosis I. Arterial Thrombosis (Embolism) in the Cat. J Small Anim Pract 1966; 7: 711-717
17 Meier H, Hoag W. Studies on the Left Auricular Thrombosis in Mice. Exp Med Surg 1961; 19: 317-322
18 Makik AB, Vanderzee H. Mechanisms of Pulmonary Edema Induced by Microembolization in Dogs. Circ Res 1978; 42: 72-79
19 Johnson A, Malik AB. Effect of Heparin on Pulmonary Edema after Microembolization in Rats. Thromb Res 1979; 16: 329-333
20 Giles AR, Johnson M, Hoogendoorn H, Blajchman M, Hirsh J. The Thrombogenicity of Prothrombin Complex Concentrates. 1. The Relationship Between In Vitro Characteristics and In Vivo Thrombogenicity in Rabbits. Thromb Res 1980; 17: 353-366
21 Dodds WJ. Second International Registry of Animal Models of Thrombosis and Hemorrhagic Diseases. ILAR News 1981; XXIV R1-R50
22 Goddard J, Lewis RM, Alcala H, Zeller RS. Intraventricular Hemorrhage - An Animal Model. Biol Neonate 1980; 37: 39-52
23 Ment LR, Steward WB, Duncan CC, Lambrecht R. Beagle Puppy Model of Intraventricular Hemorrhage. J Neurosurg 1982; 57: 219-223
24 Kotas RV, Wells TJ, Mims LC, Trainor EJ, Wiles CL. A New Model for Neonatal Pulmonary Hemorrhage Research. Pediatr Res 1975; 9: 161-165
25 Touloukian RJ, Posch JN, Spencer R. The Pathogenesis of Ischemic Gastroenterocolitis of the Neonate: Selective Gut Mucosal Ischemia in Asphyxiated Neonatal Piglets. J Pediat Surg 1972; 7: 194-205
26 Stahlman M, LeQuire VS, Young WC, Merrill RE, Birmingham RT, Payne GA, Gray J. Pathophysiology of Respiratory Distress in Newborn Lambs. Amer J Dis Child 1984; 108: 375-393
27 Hawkey C. Comparative Mammalian Haematology. Heinneman Scientific and Medical Publications; London: 1975
28 Hawkey C, Stafford JL. Influence of Serum Factors on the Species Specificity of Tissue Thromboplastin. Nature 1961; 191: 92b
29 Hawkey C. Animal Models of Thrombosis and Hemorrhage Diseases (Hemostasis in Mammals). Published U.S. Dept of Health, Education, and Welfare; 1975: 69-86
30 Hathaway WE. Coagulation Problems in the Newborn Infant. Pediatric Clinics of North America 1970; 17: 929
31 Bleyer WA, Hakami N, Shepare TH. The Development of Hemostasis in the Human Fetus and Newborn Infant. Fetal Newborn Med 1971; 79: 838
32 Sdell EJ, Corrigan Jr JJ. Platelet Counts, Fibrinogen Concentrations, and Factor V and Factor VIII Levels in Healthy Infants According to Gestational Age. Pediatr Res 1973; 7: 638
33 Jensen AH, Josso F, Zamet P, Monset-Couchard M, Minkowski A. Evolution of Blood Clotting Factor Levels in Premature Infants During the First 10 Days of Life: A Study of 96 Cases with Comparison Between Clinical Status and Blood Clotting Factor Levels. Pediatr Res 1973; 7: 638
34 Holmberg L, Henriksson P, Ekeuland H, Astedt B. Coagulation in the Human Fetus. Pediatrics 1974; 85: 860
35 Barnard DR, Simmons MA, Hathaway WE. Coagulation Studies in Extremely Premature Infants. Pediatr Res 1979; 13: 1330
36 Allstatt LB, Dennis LH, Sondell H. et al. Disseminated Intravascular Coagulation in Hyaline Membrane Disease. Biol Neonate 1971; 19: 240
37 Chessela JM, Wiggelsworth JS. Coagulation Studies in Preterm Infants with Respiratory Distress and Intracranial Hemorrhage. Arch Dis Child 1972; 47: 564
38 McDonald MM, Johnson ML, Rumack CM, Koops BL, Guggenheim MA, Babb C, Hathaway WE. Role of Coagulopathy in Newborn Intracranial Hemorrhage. Pediatrics 1984; 74: 26-31
39 Hutter Jr JJ, Hathaway WE, Wayne EQ. Hematologic Abnormalities in Severe Neonatal Necrotizing Enterocolitis. J Pediatr 1976; 88: 1026
40 Chadd MA, Elwood PC, Gray OP. et al. Coagulation Defects in Hypoxic Full Term Newborn Infants. Brit Med J 1971; 4: 516
41 Chessels JM, Wiggelsworth JS. Coagulation Studies in Severe Birth Asphyxia. Arch Dis Child 1971; 46: 705
42 Kurnetz R, Bernstein J. Neonatal Blood Loss and Hematuria. J Pediatr 1974; 84: 452
43 Hathaway WE, Mahasondana C, Makowski EL. Cord Blood Coagulation Studies in Infants of High Risk Pregnant Women. Amer J Obstet Gynecol 1975; 121: 51
44 Hathaway WE, Mull MM, Pechet GS. Disseminated Intravascular Coagulation in the Newborn. Pediatrics 1969; 43: 233-240
45 Dairaku M, Sueishi K, Tanaka K. Disseminated Intravascular Coagulation in Newborn Infants. Path Res Pract 1982; 174: 106-115
46 Davies PP. Coagulation Defects Due to Anticonvulsant Drug Treatment in Pregnancy. Lancet 1970; 1: 413
47 Mountain KR, Hirsh J, Gallus AS. Neonatal Coagulation Defect Due to Anticonvulsant Drug Treatment in Pregnancy. Lancet 1966; 1: 267
48 Oppenheimer EH, Esterly JR. Thrombosis in the Newborn: Comparison Between Infants of Diabetic and Nondiabetic Mothers. J Pediatr 1965; 67: 549
49 Legrele C, Felix JM, Droulle-Bertignon C, Potron G, Jacquot R. Evolution of Fibrinogen Levels in Rat Fetal and Maternal Blood During Gestation. Biol Neonate 1978; 33: 201-206
50 Zhukova TP, Hallman M. Effect of Acute Perinatal Asphyxia on Development of the Lung and Brain in the Rat. Biol Neonate 1982; 41: 183-192
51 Fahim MS, HallD G, Jones TM, Fahim Z, Whitt FD. Drug-Steroid Interaction in the Pregnant Rat Fetus and Neonate. Amer J Obstet Gynecol 1970; 107: 1250-1258
52 Solomon GE, Hilgartner MW, Kutt H. Coagulation Defects Caused by Diphenylhydantoin. Neurology 1972; 22: 1165-1171
53 Gerken DK, Yeary RA. Effect of Anticonvulsants on In Vitro Prothrombin Synthesis in Adult and Fetal Rat Liver. Toxicol Appl Pharmacol 1981; 61: 393-398
54 Chignier E, Baguet J, Dessapt B, Bellevile J, Descotes Y, Eloy R. Skin Healing and Fibrin Stabilizing FactorBlood Levels in the Rabbit Fetus. J Surg Res 1981; 31: 415-432
55 Hathaway WE, Hathaway HS, Belbusen LP. Coagulation Factors in Newborn Animals. J Lab Clin Med 1964; 63: 784-790
56 Sugimoto T, Yasuhara A, Matsumura T. Intracranial Hemorrhage Following Administration of Sodium Bicarbonate in Rabbits. Brain Dev 1981; 3: 297-303
57 Solomon GE, Hilgartner MW, Kutt H. Phenobarbital-Induced Coagulation Defects in Cats. Neurology 1974; 24: 920-924
58 Turbeville DF, Browen FW, Killam AP. Intracranial Hemorrhage in Kittens: Hypernatremia Versus Hypoxia. J Pediatr 1976; 89: 294-297
59 Hathaway WE, Henderson BJ. Effect of Hypoxia on Coagulation Factors in the Newborn Dog. Biol Neonate 1968; 13: 26-33
60 Goddard-Finegold J, Michael LH. Cerebral Blood Flow and Experimental Intraventricular Hemorrhage. Pediatr Res 1984; 18: 7-11
61 Ment LR, Stewart WB, Duncan CC, Scott DT, Lambrecht R. Beagle Puppy Model of Intraventricular Hemorrhage. Effect of Indomethacin on Local Cerebral Glucose Utilization. J. Neurosurg 1984; 60: 737-742
62 Culbertson Jr R, Abildgaard CF, Harrison J, Jefcoat K, Osburn BI. Ontogeny of Bovine Hemostasis. Am J Vet Res 1979; 40: 1402-1405
63 Dodds JW. The Pig Model for Biomedical Research. Fed Proc 1982; 41: 247-256
64 Massicotte P, Mitchell L, Andrew M. Animal Models of Neonatal Coagulation. Thromb Haemostas 1985; 54: 258 (Abstr)
65 Sandholm M, Honkanen-Buzalski T. Prevention of Navel Bleeding in Piglets Preparturient Administration of Ascorbic Acid. Vet Rec 1979; 104: 337-338
66 Randall G CB. Daily Changes in the Blood of Conscious Pigs with Catheters in Foetal and Uterine Vessels During Late Gestation. J Physiol 1977; 270: 719-731
67 Alward CT, Hook JB, Helmrath TA, Mattson JC, Bailie MD. Effects of Asphyxia on Cardiac Output and Organ Blood Flow in the Newborn Piglet. Pediatr Res 1978; 12: 824-827
68 Kisker CT, Robillard JE, Clarke WR. Development of Blood Coagulation - A Fetal Lamb Model. Pediatr Res 1981; 15: 1045-1050
69 Creasy RK, Drost M, Green MV, Morris JA. Determination of Foetal, Placental and Neonatal Blood Volumes in the Sheep. Circ Res 1970; 27: 487
70 Caton D, Wilcox CJ, Abrams R, Barron DH. The Circulating Plasma Volume of the Fetal Lamb as an Index of its Weight and Rate of Weight (g/day) in the Last Third of Gestation. Quarterly J Exper Physiol 1975; 60: 45
71 Fantl P, Ward HA. Clotting Activity of Maternal and Foetal Sheep Blood. J Physiol 1960; 150: 607-620
72 Fisher SH, Schwartz M, Gottlieb A, BenYoseph N, Shapiro S. Fibrinolysis, Fibrinogen and Factor XIII in Newborn Infants. Thrombosis et Diathesis Haemorrhagica 1968; 20: 542-547
73 Henriksson P, Hedner U, Nilsson I, Boehm J, Robertson B, Lorand L. Fibrin-Stabilizing Factor (Factor XIII) in the Fetus and the Newborn Infant. Pediatr Res 1974; 8: 789
74 Reynolds ML, Evans C AN, Reynolds E OR, Saunders NR, Durbin GM, Wigglesworth JS. Intracranial Haemorrhage in the Preterm Sheep Fetus. Early Hum Dev 1979; 2: 163-186
75 Wheeler AS, Sadri S, Gutsche BB, DeVore JS, David-Mian Z, Latyshevsky H. Intracranial Hemorrhage Following Intravenous Administration of Sodium Bicarbonate or Saline Solution in the Newborn Lamb Asphyxiated In Utero. Anesthesiology 1979; 51: 517-521
76 Ting P, Yamaguchi S, Bacher JD, Killens RH, Myers RE. Failure to Produce Germinal Matrix or Intraventricular Hemorrhage by Hypoxia, Hypo-, or Hypervolemia. Exper Neural 1984; 83: 449-460
77 Hecker JF, Fisk GC, Gupta JM, Abrahams N, Cockington RA, Lewis BR. Thrombus Formation on Catheters in Newborn Lambs. Anaesth Intens Care 1979; 7: 239-243
78 deLemos RA. The Role of Hyperosmolar Formulas in Necrotizing Enterocolitis. In: Necrotizing Entercolitis in the Newborn Infant, Report of the 68th Ross Conference on Pediatric Research. Moore TD. (ed) 1975
79 Kisker CT, Robillard JE, Clarke WR. Blood Coagulation Changes after Hypoxemia: A Fetal Lamb Model. Pediatr Res 1982; 16: 8-12
80 Kisker CT, Robillard JE, Clarke WR. Blood Coagulation Changes Following Hypoxemia in the Near-Term Fetal Lamb. Pediatr Res 1982; 16: 732-739
81 Kisker CT, Robillard JE, Bohlken DP. Glucocorticoid Stimulation of Blood Coagulation Factor Activities in the Fetal Lamb. J Lab Clin Med 1983; 101: 569-575
82 Kisker CT, Bohlken DP, Clarke WR. Effects of Acidosis on Fetal and Maternal Blood Coagulation: A Fetal Lamb Model. Pediatr Res (in press, 1985; Vol 19)
83 Goldsmith JC, Kisker CT. Acidosis Affects Fetal Vascular Prostacyclin Release. Thromb Res 1984; 36: 79-82
84 Goldsmith JC, Kisker CT. Thrombin-Endothelial Cell Interactions: Critical Importance of Endothelial Cell Vessel of Origin. Thromb Res 1982; 25: 131-136