Thromb Haemost 1987; 57(02): 235
DOI: 10.1055/s-0038-1651103
Letters to the Editor
Schattauer GmbH Stuttgart

Dipyridamole Inhibits Leukotriene B4 Synthesis

Paolo Gresele
Center for Thrombosis and Vascular Research, University of Leuven, B-3000 Leuven, Belgium
,
Jef Amout
Center for Thrombosis and Vascular Research, University of Leuven, B-3000 Leuven, Belgium
,
Jos Vermylen
Center for Thrombosis and Vascular Research, University of Leuven, B-3000 Leuven, Belgium
› Author Affiliations
Further Information

Publication History

Received 23 October 1986

Accepted after revision 18 December 1986

Publication Date:
23 July 2018 (online)

 
  • References

  • 1 Gresele P, Zoja C, Deckmyn H, Arnout J, Vermylen J, Verstraete M. Dipyridamole inhibits platelet aggregation in whole blood. Thromb Haemostas 1983; 50: 852-856
  • 2 Harker LA, Kadatz RA. Mechanism of action of dipyridamole. Thromb Res 1983; Suppl IV 39-46
  • 3 Gresele P, Arnout J, Deckmyn H, Vermylen J. Mechanism of the antiplatelet action of dipyridamole in whole blood: modulation of adenosine concentration and activity. Thromb Haemostas 1986; 55: 12-18
  • 4 Gresele P, Arnout J, Coene MC, Deckmyn H, Vermylen J. Leukotriene B4production by stimulated whole blood: comparative studies with isolated polymorphonuclear cells. Biochem Biophys Res Commun 1986; 137: 334-342
  • 5 Morisaki N, Stitts JM, Bartels-Tomei L, Milo GE, Panganamala RR, Cornwell DG. Dipyridamole: an antioxidant that promotes the proliferation of aorta smooth muscle cells. Artery 1982; 11: 88-107
  • 6 Deckmyn H, Gresele P, Arnout J, Todisco A, Vermylen J. Prolonging prostacyclin production by nafazatrom or dipyridamole. Lancet 1984; 2: 410-411
  • 7 Cashman J. Leukotriene biosynthesis inhibitors. Pharmaceut Res 1985; 6: 253-261
  • 8 Egan RW, Tischler AN, Baptista EM, Ham EA, Soderman DD, Gale PH. Specific inhibition and oxidative regulation of 5-lipoxygenase. Adv Prostagl Thrombox Leukotriene Res 1983; 11: 151-157
  • 9 Schaub R, Yamashita A. Leukocyte mediated vascular injury and thrombosis is reduced by an inhibitor of 5-lipoxygenase: an in vivo study. Thromb Haemostas 1985; 54: 233 (Abstr)
  • 10 Hermann KS. Lipoxygenase products: leukotrienes C4, D4, A4’s breakdown products and 12-HPETE influence platelet aggregation in vivo. Prostaglandins 1985; 29: 459-465
  • 11 Mehta P, Mehta J, Lawson D, Krop I, Letts LG. Leukotrienes potentiate the effects of epinephrine and thrombin on human platelet aggregation. Thromb Res 1986; 41: 731-738
  • 12 Piper PJ. Formation and actions of leukotrienes. Physiol Rev 1984; 64: 744-761