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Thromb Haemost 1987; 57(03): 269-272
DOI: 10.1055/s-0038-1651114
Original Article
Schattauer GmbH Stuttgart

Effect of Omega-3 Fatty Acid Supplementation on Platelet Aggregability and Platelet Produced Thromboxane

Riitta Salonen
The Kuopio Research Institute of Exercise Medicine, Kuopio, Department of Biomedical Sciences, University of Tampere, Tampere, and Departments of Medicine and Community Health, University of Kuopio, Kuopio, Finland
,
Tapio Nikkari
The Kuopio Research Institute of Exercise Medicine, Kuopio, Department of Biomedical Sciences, University of Tampere, Tampere, and Departments of Medicine and Community Health, University of Kuopio, Kuopio, Finland
,
Kari Seppänen
The Kuopio Research Institute of Exercise Medicine, Kuopio, Department of Biomedical Sciences, University of Tampere, Tampere, and Departments of Medicine and Community Health, University of Kuopio, Kuopio, Finland
,
Juha M Venäläinen
The Kuopio Research Institute of Exercise Medicine, Kuopio, Department of Biomedical Sciences, University of Tampere, Tampere, and Departments of Medicine and Community Health, University of Kuopio, Kuopio, Finland
,
Merja Ihanainen
The Kuopio Research Institute of Exercise Medicine, Kuopio, Department of Biomedical Sciences, University of Tampere, Tampere, and Departments of Medicine and Community Health, University of Kuopio, Kuopio, Finland
,
Viljo Rissanen
The Kuopio Research Institute of Exercise Medicine, Kuopio, Department of Biomedical Sciences, University of Tampere, Tampere, and Departments of Medicine and Community Health, University of Kuopio, Kuopio, Finland
,
Rainer Rauramaa
The Kuopio Research Institute of Exercise Medicine, Kuopio, Department of Biomedical Sciences, University of Tampere, Tampere, and Departments of Medicine and Community Health, University of Kuopio, Kuopio, Finland
,
Jukka T Salonen
The Kuopio Research Institute of Exercise Medicine, Kuopio, Department of Biomedical Sciences, University of Tampere, Tampere, and Departments of Medicine and Community Health, University of Kuopio, Kuopio, Finland
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Publikationsverlauf

Received 15. September 1986

Accepted after revision 12. Februar 1987

Publikationsdatum:
06. Juli 2018 (online)

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Summary

We investigated the sustained effect of 12-week supplementation of 2.880 g/day of omega-3 fatty acids on platelet aggregability, platelet produced thromboxane B2 concentration and serum fatty acid composition in a double-blind controlled trial in 44 healthy mildly overweight eastern Finnish men recruited from a representative population sample. The supplementation was discontinued seven days before the biochemical measurements. Body weight, alcohol consumption and dietary composition remained constant during the study. Even though the percentage of eicosapentaenoic acid (20:5ω3) in total serum lipids increased by 37% (p <0.01) and that of dihomo-gamma-linolenic acid (20:3ω6) decreased by 18% (p <0.01) more in the omega-3 supplemented than placebo group during supplementation, there were no significant differences in the changes in either the ADP induced platelet aggregation or in vitro platelet produced thromboxane B2 concentration between the groups. These data suggest that omega-3 fatty acids have no detectable sustained effect either on ADP induced platelet aggregation or on thromboxane produced by the platelets in vitro.

Keywords

ω-3 fatty acids - Fish oil - Thrombocyte aggregation - Prostaglandins