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Thromb Haemost 1987; 57(03): 322-325
DOI: 10.1055/s-0038-1651125
Original Article
Schattauer GmbH Stuttgart

Hemorheological Changes in Elderly Subjects-Effect of Pentosan Polysulfate and Possible Role of Leucocyte Arachidonic Acid Metabolism

G Freyburger
*   The INSERM U.8, Bordeaux, France
,
F Larrue
*   The INSERM U.8, Bordeaux, France
,
G Manciet
**   The Centre F. Magendie, Hôpital du Haut-Lévêque, Bordeaux, France
,
M F Lorient-Roudaut
*   The INSERM U.8, Bordeaux, France
,
J Larrue
*   The INSERM U.8, Bordeaux, France
,
M R Boisseau
*   The INSERM U.8, Bordeaux, France
› Institutsangaben
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Publikationsverlauf

Received 18. August 1986

Accepted after revision 24. Februar 1987

Publikationsdatum:
26. Juli 2018 (online)

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Summary

The effects of pentosan polysulfate (PPS) on various hemorheological parameters were studied in a group of very elderly subjects in good general health. Alterations in blood viscosity and filterability were detected in these patients, without any concomitant changes in factors which are known to affect these parameters: notably hematocrit, fibrinogen and plasma lipid levels. The hemorheological abnormalities were considerably improved by twice daily treatment with 50 mg of PPS (i.m.).

Apart from its anticoagulant activity, PPS has been shown to have an anti-inflammatory action. We were interested to investigate its effects on metabolism of exogenous arachidonic acid (AA) by both platelets and leucocytes. It is becoming increasingly recognized that metabolites of AA via the 5 LO pathway appear to play a role in inflammatory processes. In this study, PPS was found to inhibit leucocyte 5 LO activity. Reduction in the levels of these metabolites may therefore have an effect on whole blood rheology.

Keywords

Elderly - Pentosan polysulfate - Hemorheology - Arachidonic acid - Leucotrienes - Leucocyte
 

  • References

  • 1 Ciuffetti G, Parnetti L, Senin U. Hemorheological factors in a group of elderly patients with acute mental confusion. Clin Hemorheol 1984; 4: 341-361
    PubMedSuche in Google Scholar
  • 2 Joffe SN. Drug prevention of post operative deep vein thrombosis. A comparative study of calcium heparinate and sodium pentosane polysulfate. Arch Surg 1976; 111: 37-40
    CrossrefPubMedSuche in Google Scholar
  • 3 Reid HL, Barnes JA, Lock PJ, Dormandy JA, Dormandy TL. A simple method for measuring erythrocyte deformability. J Clin Path 1976; 26: 855-858
    PubMedSuche in Google Scholar
  • 4 Fischer AM, Barrowcliffe TW, Thomas DP. A comparison of pentosan polysulfate (SP54) and heparin. Mechanism of action on blood coagulation. Thromb Haemostas 1982; 47: 104-108
    PubMedSuche in Google Scholar
  • 5 Freyburger G, Vergnes C, Hourdille P, Boisseau MR, Sanchez R, Cutillas M, Perro G. Etude biologique de l’action du polysulfate de pentosane chez les brûlés graves. Ann Chir 1984; 38: 247-252
    PubMedSuche in Google Scholar
  • 6 Rijken DC, Juhan-Vague I, De Cock F, Collen D. Measurement of human tissue-type plasminogen activator by a two-site immunoradiometric assay. J Lab Clin Med 1983; 101: 274-284
    PubMedSuche in Google Scholar
  • 7 Vanderhoeck JY, Bailey JM. Activation of a 15 Lipoxygenase/ leukotriene pathway in human polymorphonuclear leukocytes by the Anti-Inflammatory Agent Ibuprofen. J Biol Chem 1984; 259: 6752-6756
    PubMedSuche in Google Scholar
  • 8 Craddock PR, Hammerschmidt D, White JG, Dalmasso AP, Jacob HS. Complement (C5a) induced granulocyte aggregation in vitro. J Clin Invest 1977; 60: 260-264
    CrossrefPubMedSuche in Google Scholar
  • 9 Stuart J. The acute phase reaction and hematological stress syndrome in vascular disease. Thromb Res 1980; 17: 831-840
    CrossrefPubMedSuche in Google Scholar
  • 10 Thomas DP, Barrowcliffe TW, Merton RE, Stocks J, Dawes J, Pepper DS. In vitro release of anti Xa clotting activity by a heparin analog. Thromb Res 1980; 17: 831-840
    CrossrefPubMedSuche in Google Scholar
  • 11 Ehrly AM, Muller HE. Aggregation und Desaggregation von Erythrozyten. Acta Haematol 1966; 36: 323-334
    CrossrefPubMedSuche in Google Scholar
  • 12 Goetzl EJ, Pickette WC. Novel structural determinants of the human neutrophil chemotactic activity of leucotriene B. J Exp Med 1981; 153: 482-487
    CrossrefPubMedSuche in Google Scholar
  • 13 Smith M JH, Walker JR. The effects of some antirheumatic drugs on an in vitro model of human polymorphonuclear leucocyte chemokinesis. Br J Pharmacol 1980; 69: 473-478
    CrossrefPubMedSuche in Google Scholar
  • 14 O’Flaherty JT, Thomas MJ, Lousart SL, Salzer WL, Mc Call CE. Neutropenia induced by systemic infusion of 5-12 dihydroxy-6-8-10-14 eicosatetraenoic acid, correlation with its in in vitro effects upon neutrophils. J Clin Invest 1982; 69: 993-998
    CrossrefPubMedSuche in Google Scholar
  • 15 O’Flaherty JT, Showell HJ, Becker EL, Ward PA. Neutrophil aggregation and degranulation. Am J Pathol 1979; 95: 433-444
    PubMedSuche in Google Scholar
  • 16 Ford-Hutchinson AW, Bray MA, Smith M JH. The aggregation of rat neutrophils by arachidonic acid pathway: a possible bioassay for lipoxygenase activity. J Pharmacol 1979; 31: 868-869
    CrossrefPubMedSuche in Google Scholar
  • 17 Chien S. Electrochemical interactions between erythrocyte surfaces. Thromb Res 1976; 8: 189-202
    CrossrefPubMedSuche in Google Scholar
  • 18 Bruhn HD. Rheological consequences of fibrinolysis and of anticoagulation. Clin Hemorheol 1984; 4: 29-34
    PubMedSuche in Google Scholar
  • 19 Laghi-Pasini F, Pasqui AL, Ceccatelli L, Capecchi L, Orrico A, Di Perri T. Heparin inhibition of polymorphonuclear leukocyte activation in vitro. A possible pharmacological approach to granulocytemediated vascular damage. Thromb Res 1984; 35: 527-537
    CrossrefPubMedSuche in Google Scholar