Rebuttal: Synergism of Tissue-Type Plasminogen Activator (t-PA) and Single-Chain Urokinase-Type Plasminogen Activator (scu-PA) on Clot Lysis In Vitro and a Mechanism for this Effect

Thromb Haemost 1987; 57(03): 373
DOI: 10.1055/s-0038-1651136

Letters to the Editor

Schattauer GmbH Stuttgart

D Collen

Center for Thrombosis and Vascular Research, University of Leuven, Belgium

References
1 Gurewich V, Pannell R. Synergism of tissue plasminogen activator (t-PA) and single-chain urokinase-type plasminogen activator (scu-PA) on clot lysis in vitro and a mechanism for this effect. Thromb Haemostas 1987; 57: 372
2 Collen D, De Cock F, Demarsin E, Lijnen HR, Stump DC. Absence of synergism between tissue-type plasminogen activator (t-PA), singlechain urokinase-type plasminogen activator (scu-PA) and urokinase on clot lysis in a plasma milieu in vitro. Thromb Haemostas 1986; 56: 35-39
3 Gurewich V, Pannell R. A comparative study of the efficacy and specificity of tissue plasminogen activator and pro-urokinase: demonstration of synergism and of different tresholds of non-selectivity. Thromb Res 1986; 44: 217-228
4 Berenbaum MC. Synergy, additivism and antagonism in immunosuppression. Clin exp Immunol 1977; 28: 1-18
5 Lijnen HR, Zamarron C, Blaber M, Winkler ME, Collen D. Activation of plasminogen by pro-urokinase. I. Mechanism J Biol Chem 1986; 261: 1253-1258
6 Collen D, Stump DC, Van de Werf F. Coronary thrombolysis in patients with acute myocardial infarction by intravenous infusion of synergic thrombolytic agents. Am Heart J 1986; 112: 1083-1084