The Effect of Urea on the Aggregation of Normal Human Platelets

J. B Somer; J. H Stewart; P. A Castaldi

doi:10.1055/s-0038-1651181

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1968; 19(01/02): 064-069
DOI: 10.1055/s-0038-1651181

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

The Effect of Urea on the Aggregation of Normal Human Platelets

J. B Somer^*

¹Department of Haematology, Royal Prince Alfred Hospital, Sydney

²Department of Medicine, University of Sydney and the Renal Unit and Medical Research Department, Kanematsu Memorial Institute, Sydney Hospital, Sydney Australia

,

J. H Stewart

¹Department of Haematology, Royal Prince Alfred Hospital, Sydney

²Department of Medicine, University of Sydney and the Renal Unit and Medical Research Department, Kanematsu Memorial Institute, Sydney Hospital, Sydney Australia

,

P. A Castaldi

¹Department of Haematology, Royal Prince Alfred Hospital, Sydney

²Department of Medicine, University of Sydney and the Renal Unit and Medical Research Department, Kanematsu Memorial Institute, Sydney Hospital, Sydney Australia

› Author Affiliations

Abstract

Summary

Studies have been performed on the effect of urea on platelet aggregation. Over a wide concentration range, urea initially inhibits and later enhances aggregation induced by ADP, thrombin, adrenaline and nor-adrenaline. Urea induces aggregation by a mechanism which differs from that due to ADP and it is suggested that this may reflect platelet damage. Urea alone cannot be held responsible for the qualitative platelet abnormalities and bleeding tendency of the uraemic state, but it may number among a group of harmful influences.

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References

References
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