RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00035024.xml
Thromb Haemost 1968; 20(01/02): 078-087
DOI: 10.1055/s-0038-1651250
DOI: 10.1055/s-0038-1651250
Originalarbeiten – Original Articles – Travaux Originaux
Kinetic Aspects of the Interaction of Blood-Clotting Enzymes
VI. Localization of the Site of Blood-Coagulation Inhibition by the Protein Induced by Vitamin K Absence (PIVKA)Weitere Informationen
Publikationsverlauf
Publikationsdatum:
27. Juni 2018 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/196802/lookinside/thumbnails/10-1055-s-0038-1651250-1.jpg)
Summary
PIVKA, the circulating anticoagulant protein found in vitamin K deficiency can, on kinetical grounds, be recognized as an analogue of factor X. The existence of analogues of other vitamin K-dependent clotting factors cannot be ruled out, but need not be assumed to explain the experimental results.
-
References
- 1 Altman R, Hemker H.C. Contact activation of the extrinsic blood clotting system. Thrombos. Diathes. haemorrh. (Stuttg.) 1967; 18: 525
- 2 Davies E.W, Ratnoff O.D. A waterfall sequence for intrinsic blood clotting. Science 1964; 145: 1310
- 3 Haanen C, Morselt G, Schoenmakers J. Contact activation of Hageman Factor and the interaction of Hageman Factor and plasma thromboplastin antecedent. Thrombos. Diathes. haemorrh. (Stuttg.) 1967; 17: 307
- 4 Hemker H.C. Kinetic aspects of the interaction of bloodclotting enzymes. V. The reaction mechanism of the extrinsic clotting system as revealed by the kinetics of onestage estimations of coagulation enzymes. Thrombos. Diathes. haemorrh. (Stuttg.).(In press.).
- 5 Hemker H.C, Esnouf M.P, Hemker P.W, Swart A.C.W, Macfarlane R.G. Kinetics of the formation of prothrombin converting activity in a purified system. Nature (Lond.) 2481 215: 967
- 6 Hemker H.C, Hemker P.W. Kinetic aspects of the interaction of bloodclotting enzymes. IV. Kinetics of competitive inhibition in clotting tests. Thrombos. Diathes. haemorrh. (Stuttg.).(In press.).
- 7 Hemker H.C, Kahn M.J.P. The reaction sequence of blood coagulation. Nature (Lond.) 1967; 215: 1201 no 5106
- 8 Hemker H.C, Veitkamp J.J, Loeliger E.A. Kinetic aspects of the interaction of bloodclotting enzymes, III. Demonstration of an inhibitor of prothrombin conversion in vitamin K deficiency. Thrombos. Diathes. haemorrh. (Stuttg.) 1968; 19: 346
- 9 Hemker H.C, Siepel T.V, Altman R, Loeliger E.A. Kinetic aspects of the interaction of bloodclotting enzymes, II. The relation between clotting time and plasma concentration in prothrombintime estimations. Thrombos. Diathes. haemorrh. (Stuttg.) 1967; 17: 349
- 10 Kahn M.J. P. Interaction of hydrophobic surfaces and the blood coagulation promoting proteins. F. E. B. S. Meeting, Oslo. Abstract 51:13.
- 11 Macfarlane R.G. An enzyme cascade in blood clotting mechanisms and its function as a biochemical amplifier. Nature (Lond.) 1964; 202: 490
- 12 Newcomb T.F, Hoshida M. Factor V and thrombin Scand. J. clin. Lab. Invest 1963; 17: 61 suppl. 84
- 13 Owren P.A. Thrombotest. A new method for controlling anticoagulant therapy. Lancet 1959; II: 754
- 14 Owren P.A, Aas K. The control of Dicumarol therapy and the quantitative determination of prothrombin and proconvertin. Scand. J. clin. Lab. Invest 1961; 3: 169
- 15 Rapaport S.I, Hjort P.F, Patch M.J. Further evidence that thrombinactivation of Factor VIII is an essential step in intrinsic clotting. Scand. J. clin. Lab. Invest 1965; 17 (Suppl. 84) 88 (suppl)