Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1968; 20(01/02): 144-154DOI: 10.1055/s-0038-1651255 Originalarbeiten – Original Articles – Travaux Originaux Schattauer GmbH A Circulating Anticoagulant Directed against Antihaemophilic Globulin (Factor VIII) Combined with Thrombocytopenia Report of a Case Successfully Treated by an Immunosuppressive Agent[*] G Winckelmann 1 Department of Medicine (Commiss. Director: Prof. Dr. J. Schirmeister), University of Freiburg, Germany , D Böttcher 1 Department of Medicine (Commiss. Director: Prof. Dr. J. Schirmeister), University of Freiburg, Germany , R Groh 1 Department of Medicine (Commiss. Director: Prof. Dr. J. Schirmeister), University of Freiburg, Germany , with Technical Assistance by M. Rehe › Author Affiliations Recommend Article Abstract PDF Download Buy Article Summary A circulating anticoagulant directed against factor VIII (antihaemophilic globulin) is described which developed in association with thrombocytopenia in an otherwise apparently healthy woman. Inactivation of factor VIII by this inhibitor was shown to be progressive and temperature dependent. The circulating anticoagulant was not species specific and produced temporary factor VIII deficiency when injected into dogs. Administration of large doses of corticosteroids to the patient did not affect the factor VIII inhibitor and resulted only in a temporary increase in the platelet counts. In the course of subsequent immunosuppressive treatment with azathioprine, the inhibitor disappeared and clinical symptoms improved, whereas thrombocytopenia persisted. PDF (1807 kb) References References 1 Andersen B.R, Terry W.D. Gamma G4-globulin antibody causing inhibition of clotting factor VIII. 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