Inhibition by Dipyridamole of Arterial Thrombosis in Rats

Paul Didisheim

doi:10.1055/s-0038-1651265

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1968; 20(01/02): 257-266
DOI: 10.1055/s-0038-1651265

Originalarbeiten – Original Articles – Travaux Originaux

Schattauer GmbH

Inhibition by Dipyridamole of Arterial Thrombosis in Rats

Paul Didisheim M. D.

¹Section of Clinical Pathology, Mayo Clinic, Rochester, Minnesota

› Author Affiliations

Abstract

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Summary

Thrombi in mesenteric arteries of the rat were produced by electric means. The effectiveness of 4 agents – heparin, aspirin, warfarin, and dipyridamole – in modifying arterial thrombosis was examined with this model. Heparin and aspirin had equivocal beneficial effects. Warfarin had a deleterious effect: the duration of complete occlusion was prolonged. In striking contrast, dipyridamole induced a marked shortening in the duration of complete thrombotic occlusion. On reinjection of the drug, occlusion was almost completely suppressed.

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References

References
1 Amris C.J, Larsen V, Brøckner J. Scheme for fibrinolytic treatment with activatorfree porcine plasmin. Scand. J. clin. Lab. Invest 1966; 18: 24 Suppl. 89
2 Barker N.W, Cromer H.E, Hurn Margaret, Waugh J.M. Use of Dicumarol in the prevention of postoperative thrombosis and embolism with special reference to dosage and safe administration. Surgery 1945; 17: 207
3 Berman H.J, Fulton G.P. Platelets in the peripheral circulation. Johnson Shirley A, Monto R.W, Rebuck J.W, Horn Jr. R.C. (eds) Blood Platelets, Henry Ford Hospital International Symposium. Little, Brown & Company; Boston: 1961: 7-19
4 Böttiger L.E, Carlson L.A, Engstedt L, Orö L. The effect of longterm heparin treatment in ischaemic heart disease. J. Atheroscler. Res 1965; 5: 253
5 Callahan A.B, Lutz B.R, Fulton G.P, Degelman J. Smooth muscle and thrombus thresholds to unipolar stimulation of small blood vessels. Angiology 1960; 11: 35
6 Cowan C.R, Monkhouse F.C. Studies on electrically induced thrombosis and related phenomena. Canad. J. Physiol. Pharmac 1966; 44: 881
7 Cox E.F, Flotte C.T, Buxton R.W. Dextran in the treatment of thrombophlebitis. Surgery 1965; 57: 225
8 Emmons P.R, Harrison M.J.G, Honour A.J, Mitchell J.R.A. Effect of dipyridamole on human platelet behaviour. Lancet 1965; II: 603
9 Emmons P.R, Harrison M.J.G, Honour A.J, Mitchell J.R.A. Effect of a pyrimidopyrimidine derivative on thrombus formation in the rabbit. Nature (Lond.) 1965; 208: 255
10 Enger E, Bøyesen S. Longterm anticoagulant therapy in patients with cerebral infarction : A controlled clinical study. Acta med. scand 1965; 178: 1 Suppl. 438
11 Evans G, Nishizawa E.E, Packham M.A, Mustard J.F. The effect of acetylsalicylic acid (aspirin) on platelet function. (Abstr.) (Proceedings of the Third Conference on Blood Platelets, Oak Ridge, Tennessee, June 22-23, 1967.). Blood 1967; 30: 535 Oct. Symposium
12 Fletcher A.P, Sherry S. Thrombolytic agents. Ann. Rev. Pharmac 1966; 6: 89
13 Hoak J.C, Connor W.E, Warner E.D. The antithrombotic effects of sodium heparin and sodium warfarin. Arch. intern. Med 1966; 117: 25
14 Knisely M.H. The fused quartz rod technique for transilluminating living internal organs in situ for microscopic study. Anat. Rec 1954; 120: 265
15 Lehmann J. : Thrombosis : Treatment and prevention with methylenebis-(hydroxycoumarin). Lancet 1943; I: 611
16 Merskey C. A. Drapkin Analytical review: Anticoagulant therapy. Blood 1965; 25: 567
17 Murphy E.A, Mustard J.F, Rowsell H.C, Downie H.G. Quantitative studies on the effect of Dicumarol on experimental thrombosis. J. Lab. clin. Med 1963; 61: 935
18 Murray D.W.G, Jaques L.B, Perrett T.S, Best C.H. Heparin and the thrombosis of veins following injury. Surgery 1937; 2: 163
19 Mustard J.F, Murphy E.A, Downie H.G, Rowsell H.C. Heparin and thrombus formation: Early suppression and late enhancement. Brit. J. Haemat 1963; 9: 548
20 Nichol E.S, Keyes J.N, Borg J.F, Googan T.J, Boehrer J.J, Mullins W.L, Scott T, Page R, Griffith G.C, Massie E. Longterm anticoagulant therapy in coronary atherosclerosis. Amer. Heart. J 1958; 55: 142
21 Powley P.H. Rheomacrodex in peripheral ischemia. Amer. Heart J 1964; 67: 424
22 Salzman E.W, Harris W.H, DeSanctis R.W. Anticoagulation for prevention of thromboembolism following fractures of the hip. New Engl. J. Med 1966; 275: 122
23 Sawyer P.N, Srinivasan S. Studies on the biophysics of intravascular thrombosis. Amer. J. Surg 1967; 114: 42
24 Sawyer P.N, Suckling E.E, Wesolowski S.A. Effect of small electric currents on intravascular thrombosis in to visualized rat mesentery. Amer. J. Physiol 1960; 198: 1006
25 Schwartz S.J, Richardson J.W. Prevention of thrombosis with the use of a negative electric current. Surg. Forum 1961; 12: 46
26 Seaman A.J, Griswold H.E, Reaume R.B, Ritzman L.W. Prophylactic anticoagulant therapy for coronary artery disease: A sevenyear controlled study. J. Amer. med. Ass 1964; 189: 183
27 Sickert R.G, Whisnant J.P, Millikan C.H. Surgical and anticoagulant therapy of occlusive cerebrovascular disease. Ann. intern. Med 1963; 58: 637
28 Verstraete M, Vermylen J, Amery A, Vermylen C. Thrombolytic therapy with streptokinase using a standard dosage scheme. Brit. med. J 1966; 1: 454
29 Wasserman A.J, Gutterman L.A, Klara B, Yoe V.E, Kemp Jr. D.W. Richardson: Anticoagulants in acute myocardial infarction : The failure of anticoagulants to alter mortality in a randomized series. Amer. Heart J 1966; 71: 43
30 Wessler S. Studies in intravascular coagulation, II. A comparison of the effect of Dicumarol and heparin on clot formation in isolated venous segments. J. clin. Invest 1953; 32: 650
31 Whisnant J.P, Millikan C.H, Sayre G.P, Wakim K.G. Effect of anticoagulants on experimentai cerebral infarction: Clinical implications. Circulation 1959; 20: 56
32 Williams R.D, Carey L.C. Studies in the production of “standard„ venous thrombosis. Ann. Surg 1959; 149: 381
33 Wright I.S. The case for anticoagulant therapy. Circulation 1964; 30: 447