Summary and Conclusions
In conjunction with experiments designed to test the effects of infusing acetylated
thrombin (Thrombin E) and Clotting thrombin (Thrombin C) into dogs, the occurrence
of hemolysis was noted. Serial observations on its magnitude, its relationship to
thrombin-induced defibrination, and the formation of thrombi were made. The findings
suggest a unique role for thrombin in inducing “in vivo” intravascular hemolysis in
short term experiments, possibly via an indirect action on red blood cells.
