Thromb Haemost 1969; 22(01): 028-031
DOI: 10.1055/s-0038-1651325
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Differences in the Effect of Antithrombin on Thrombin Clotting and Thrombin Esterase Activity[*]

H Gans
1   Department of Surgery, the New York Hospital-Cornell University Medical College, New York, N. Y. 10021
,
A Boulton
1   Department of Surgery, the New York Hospital-Cornell University Medical College, New York, N. Y. 10021
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Publikationsdatum:
10. Juni 2018 (online)

Summary

Following the addition of thrombin to serum, thrombin clotting activity rapidly disappears. During the first half hour thrombin esterase activity also declines. Subsequently, the thrombin esterase activity remains stable for a long time.

Heparin which, under these circumstances profoundly alters the thrombin clotting-activity, affects the thrombin esterase activity only slightly. Hence serum induced inhibition of thrombin esterase activity is not significantly altered by heparin.

The possible relationship of these findings to the spontaneous resolution of thrombo-emboli is discussed.

* Supported by Grant No. HE 05341 and HE 12324 from the U.S. Public Health Service, National Institutes of Health, National Heart Institute and a N.I.H. Research Career Program Award.