Preventive Effect of Pyridinolcarbamate on Thrombohemorrhagic Phenomenon and Hemorrhagic Necrosis

H Yamazaki; A Kurai; T Shimamoto

doi:10.1055/s-0038-1651335

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1969; 22(01): 145-150
DOI: 10.1055/s-0038-1651335

Originalarbeiten-Original Articles-Travaux Originaux

Schattauer GmbH

Preventive Effect of Pyridinolcarbamate on Thrombohemorrhagic Phenomenon and Hemorrhagic Necrosis

H Yamazaki

¹Institute for Cardiovascular Diseases, Tokyo Medical and Dental University School of Medicine, Yushima, Tokyo, Japan

,

A Kurai

¹Institute for Cardiovascular Diseases, Tokyo Medical and Dental University School of Medicine, Yushima, Tokyo, Japan

,

T Shimamoto

¹Institute for Cardiovascular Diseases, Tokyo Medical and Dental University School of Medicine, Yushima, Tokyo, Japan

› Author Affiliations

Abstract

Summary

Forty two rabbits were injected intravenously with 5 ml/kg of 0.5% agar solution or 100 μg/kg of bacterial endotoxin derived from Escherichia coli. After 1 min 0.1 ml of 500 μg/ml of adrenaline was injected intradermally in abdominal skin of each rabbit. After 24 hrs hemorrhage in adrenaline-injected regions was observed in 28 of 38 regions in abdominal skin of rabbits treated with agar and in 11 of 14 regions of rabbits treated with endotoxin. Both the hemorrhages were similarly reduced with the pretreatment of 40 μg of pyridinolcarbamate given locally with statistical significance (P < 0.01 and 0.05).

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References

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