Summary
We have studied the effect of complement inhibitors of various classes on platelet
aggregation induced by collagen or by latex. The majority of the complement inhibitors
which we studied inhibited collagen- or latex-induced platelet aggregation.
The possible role of complement as a mediator in the activation of platelet reactions
is discussed.
These findings indicate that some chemicals are able to act on some of the immune
reactions and also on platelet thrombogenetic reactions. It is suggested that drugs
or combination of drugs having such a polyvalence might be of particular benefit in
thrombo-immuno-inflammatory conditions.