Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1969; 22(03): 544-551DOI: 10.1055/s-0038-1651390 Originalarbeiten-Original Articles-Travaux Originaux Schattauer GmbH On the Role of the Stable Plasminogen Activator of the Venous Wall in Occlusion Induced Fibrinolytic State Authors Author Affiliations R Constantini 1 Department of Internal Medicine (Head: Prof .Dr. H. Braunsteiner), University of Innsbruck, Austria F Spöttl 1 Department of Internal Medicine (Head: Prof .Dr. H. Braunsteiner), University of Innsbruck, Austria F Holzknecht 1 Department of Internal Medicine (Head: Prof .Dr. H. Braunsteiner), University of Innsbruck, Austria H Braunsteiner 1 Department of Internal Medicine (Head: Prof .Dr. H. Braunsteiner), University of Innsbruck, Austria Recommend Article Abstract Buy Article(opens in new window) Summary The fibrinolytic activity respectively the PA activity of normal veins before and after venous occlusion is measured by the histochemical method of Todd. The results show marked decreases of PA of the adventitia and an increase of PA of the endothelial type, after venous occlusion. This suggests a transfer of PA through the venous wall into the intravascular lumen, and may be the cause of increased fibrinolytic activity in venous blood after occlusion. Contrary assumptions are discussed. Full Text References References 1 Albrechtsen O. K. Fibrinolytic activity in the organism. Acta physiol. scand.. Suppl. 165 1957 2 Amery A, Vermylen J, Maes H, Verstraete M. Enhancing the fibrinolytic activity in human blood by occlusion of blood vessels. I. The appearance of the phenomenon. Thrombos. Diathes. haemorrh. (Stuttg.) 7: 70 1962; 3 Ata M, Azeem P. S, Tighe J. R. The influence of venous occlusion on the fibrinolytic activity of blood. Clin. Sci. 27: 357 1964; 4 Clarke R. L. A, Orandi E, Cliffton E. Induction of fibrinolysis by venous obstruction. Angiology 11: 367 1960; 5 Cliffton E. E, Clarke R. L, Murphy J. Studies on fibrinolytic activity with venous occlusion: Treatment of thrombophlebitis. Surgery 50: 644 1961; 6 Constantini R, Spöttl F, Holzknecht F, Herbst M, Braunsteiner H. On the plasminogen activator content of forearm veins in patients with primary “carbohydrate-induced” hypertriglyceridemia. Coagulation (in press). 7 Fearnley G. R. Fibrinolysis. 56 Baltimore: 1965 8 Holemans R, Roberts H. R. Hageman factor and in vivo activation of fibrinolysis. J. Lab. clin. Med. 64: 778 1964; 9 Holemans R, Tysinger M. F. Site of origin of increased fibrinolytic activity during venous occlusion. Proc. Soc. exp. Biol. (N. Y.) 118: 488 1965; 10 Holzknecht F, Spöttl F, Braunsteiner H. Enhancement of fibrinolysis by venous occlusion. Results of long-term thrombelastography and activator determination. Thrombos. Diathes. haemorrh. (Stuttg.) 21: 304 1969; 11 Iatridis S. G, Iatridis P. G, Ferguson J. H. The role of HF (factor XII) in the pathogenesis of the thrombolytic state induced by venous occlusion. Thrombos. Diathes. haemorrh. (Stuttg.) 16: 207 1966; 12 Nilsson I. M, Robertson B. Effect of venous occlusion on coagulation and fibrinolytic components in normal subjects. Thrombos. Diathes. haemorrh. (Stuttg.) 20: 397 1968; 13 Nilsson I. M. Changes in the coagulation and fibrinolytic system predisposing to thrombosis. Acta chir. scand. Suppl. 387: 15 1968; 14 Pandolfi M, Robertson P, Isacson S, Nilsson I. M. Fibrinolytic activity of human veins in arms and legs. Thrombos. Diathes. haemorrh. (Stuttg.) 20: 247 1968; 15 Pandolfi M, Nilsson I. M, Robertson B, Isacson S. Fibrinolytic activity of human veins. Lancet II: 127 1967; 16 Spöttl F, Holzknecht F, Braunsteiner H. Enhancement of the fibrinolytic activity by venous occlusion in patients with primary “carbohydrate-induced” hypertriglyceridemia. Acta haemat. (Basel) 41: 154 1969; 17 Todd A.S. The histological localisation of fibrinolysin activator. J. Path. Bact. 78: 281 1959; 18 Todd A. S. The tissue activator of plasminogen and thrombosis. Thrombosis and Anticoagulant Therapy. 25. W. Walker; London, Livingstone: 1960 19 Warren B. A. Fibrinolytic activity of vascular endothelium. Brit. med. Bull. 3: 213 1964;
